Diuretic activity of the bark of Eysenhardtia polystachya

  • Saudy Saret Pablo-Pérez Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City, 07738 http://orcid.org/0000-0001-5745-6437
  • María Mirian Estévez-Carmona Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City, 07738 http://orcid.org/0000-0001-9945-8545
  • María Estela Meléndez-Camargo Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City, 07738 http://orcid.org/0000-0002-6052-0281
Keywords: Diuretic, Eysenhardtia polystachya, Furosemide


The aim of this study was to evaluate the diuretic activity of Eysenhardtia polystachya bark aqueous extract at different doses in a rat model. Different doses of E. polystachya (125, 250, 500 and 750 mg/kg body weight), furosemide (4 mg/kg) and vehicle were administered per os to female rats (n=6 animals per group). After 6 hours in metabolic cages, the effect on urinary flow, glomerular ?ltration rate and electrolyte balance of sodium and potassium were assessed in all animals. E. polystachya at the doses of 500 and 750 mg/kg induced diuretic activity, since markedly increased (p<0.05) the urinary flow rate, similar to that of furosemide treated group. Only the dose of 750 mg/kg produced an increment in urinary excretion of sodium but not of potassium compared with control group. These findings indicate that E. polystachya bark-induced diuretic activity, providing evidence for its folkloric use.


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How to Cite
Pablo-Pérez, S. S., M. M. Estévez-Carmona, and M. E. Meléndez-Camargo. “Diuretic Activity of the Bark of Eysenhardtia Polystachya”. Bangladesh Journal of Pharmacology, Vol. 11, no. 1, Jan. 2016, pp. 212-7, doi:10.3329/bjp.v11i1.24659.
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