In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth

Authors

  • Elizabeth George Department of Botany, Bharathiar University, Coimbatore
  • Muniyandi Kasipandi Department of Botany, Bharathiar University, Coimbatore
  • Mudili Vekataramana DRDO-Bharathiar University Centre for Life Sciences, Coimbatore
  • Kalagatur Naveen Kumar Defence Food Research Laboratory, Mysore
  • Joseph Anthuvan Allen DRDO-Bharathiar University Centre for Life Sciences, Coimbatore
  • Thangaraj Parimelazhagan Department of Botany, Bharathiar University, Coimbatore
  • Natarajan Gopalan DRDO-Bharathiar University Centre for Life Sciences, Coimbatore

DOI:

https://doi.org/10.3329/bjp.v11i1.24157

Keywords:

Anti-oxidant, Cytotoxic, Pogostemon mollis

Abstract

In the present study, the anti-oxidant and cytotoxic effects of the different solvent extracts of Pogostemon mollis were analyzed. The phenolic, tannin and flavonoid contents were highest in the ethyl acetate extract and analogous to the antioxidant activity results. The extracts showed activities similar to the standard anti-oxidants. The extent to which the extracts protect free radical damage on DNA was evaluated and showed good genoprotective effects. Bacterial cells and fungal spores and hyphae showed visible damages due to the treatment of ethyl acetate extract. Finally, in the cytotoxic analysis, IC50 value was calculated based on the absorbance value of different concentrations. It concluded that P. mollis is a prospective candidate for the various therapeutic applications especially its ethyl acetate extract.

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Author Biographies

Mudili Vekataramana, DRDO-Bharathiar University Centre for Life Sciences, Coimbatore

Research Scientist

Thangaraj Parimelazhagan, Department of Botany, Bharathiar University, Coimbatore

Professor

Natarajan Gopalan, DRDO-Bharathiar University Centre for Life Sciences, Coimbatore

Scientist

Published

2016-01-10

How to Cite

George, E., M. Kasipandi, M. Vekataramana, K. N. Kumar, J. A. Allen, T. Parimelazhagan, and N. Gopalan. “In Vitro Anti-Oxidant and Cytotoxic Analysis of Pogostemon Mollis Benth”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Jan. 2016, pp. 148-5, doi:10.3329/bjp.v11i1.24157.

Issue

Section

Research Articles