Effect of vitamin B12 supplementation on glycemic control in poorly controlled hyperhomocysteinemic type 2 diabetic patients

Authors

  • Yogendra Narayanrao Keche Department of Pharmacology, C. M. Medical College and Hospital, Kachandur, Durg, Chattisgarh 490024 http://orcid.org/0000-0003-0064-0019
  • Radha Yegnanarayan Smt Kashibai Navale Medical College and General Hospital, Narhe Ambegaon, Pune, Maharashtra
  • Shreepad Bhat Department of Medicine, Smt Kashibai Navale Medical College and General Hospital, Narhe Ambegaon, Pune, Maharashtra

DOI:

https://doi.org/10.3329/bjp.v11i1.24141

Keywords:

Glycemic control, Hyperhomocysteinemic, Type 2 diabetic, Vitamin B12 supplementation

Abstract

This study was conducted to observe the effect of vitamin B12 supplementation on glycemic control in poorly controlled hyperhomocysteinemic type 2 diabetic patients by measuring HbA1c levels at baseline and 4 weeks. Patient having serum homocysteine more than 15 µmol/L or vitamin B12 less than 223 pg/mL were enrolled in this study. One group received methylcobalamin 500 µg daily with their usual anti-diabetic therapy and the other group received only suitable anti-diabetic drug therapy. Methylcobalamin 500 µg was given daily for period of 4 weeks. Glycemic control was measured by levels of HbA1c, blood sugar at baseline and at 4 weeks. Serum homocysteine levels was reduced from 21.5 ± 2.6 to 15.4 ± 6.4 (p=0.04) with vitamin B12 supplementation at 4 weeks. At 4 weeks, HbA1c decreased from 9.9 ± 0.9 to 8.7 ± 0.5 (p<0.01) in vitamin B12 deficient patients after vitamin B12 supplementation. There is role of vitamin B12 in glycemic control in poorly controlled type 2 diabetic patients.

 

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Author Biographies

Yogendra Narayanrao Keche, Department of Pharmacology, C. M. Medical College and Hospital, Kachandur, Durg, Chattisgarh 490024

Associate Professor

Radha Yegnanarayan, Smt Kashibai Navale Medical College and General Hospital, Narhe Ambegaon, Pune, Maharashtra

Professor and Head, Department of Pharmacology

Shreepad Bhat, Department of Medicine, Smt Kashibai Navale Medical College and General Hospital, Narhe Ambegaon, Pune, Maharashtra

Professor and Head

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Published

2015-12-17

How to Cite

Keche, Y. N., R. Yegnanarayan, and S. Bhat. “Effect of Vitamin B12 Supplementation on Glycemic Control in Poorly Controlled Hyperhomocysteinemic Type 2 Diabetic Patients”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Dec. 2015, pp. 50-53, doi:10.3329/bjp.v11i1.24141.

Issue

Section

Clinical Trial