Nesfatin-1: Opposing role with Angiopoetin -2 in Myocardial Infarction

Abstract

Background: One of the main causes of morbidity and death in the world is myocardial infarction. Nesfatin-1, angiopoietin-2, and lipid abnormalities are risk factors linked to endothelial dysfunction and inflammation.

Objective: The purpose of this study was to compare the levels of specific lipids in heart patients with those in healthy people.

Methodology: From January 15, 2026 to May 31, 2026, this case-control study was carried out at the Maysan Center for Heart Diseases and Surgery. It comprised eighty cases, forty of which were myocardial infarction patients and forty of which were healthy controls participated in the study. Nesfatin-1 and angiopoietin-2 levels were measured along with body mass index, TC, TG, HDL-C, LDL-C, and VLDL-C. Patients with myocardial infarction had significantly higher BMI, TC, TG, LDL-C, and VLDL-C than the control group, but their HDL-C levels were significantly lower. Patients had higher levels of angiopoietin-2 and lower levels of nesfatin-1 when compared to healthy people.

Results: According to ROC analysis, certain biomarkers have a high diagnostic power in distinguishing between patients and healthy people.

Conclusion: In conclusion, lipid abnormalities are associated with myocardial infarction, especially elevated Angiopoietin-2 and decreased Nesfatin-1, suggesting their potential role in the pathophysiological processes underlying the disease's progression. This lends credence to the potential use of these biomarkers in early diagnosis and risk assessment for cardiovascular disease.

Bangladesh Journal of Infectious Diseases, June 2026;13(1):271-277