Assessment of Fertility in Mosaic Klinefelter Syndrome Patients in Baghdad City Using Karyotyping, Sister Chromatid Exchange, andSemen Analysis
Keywords:
Mosaic Klinefelter Syndrome, Mosaicism, Semen, fertilization, karyotyping, liver abscessAbstract
Background: Klinefelter’s syndrome was discovered in 1942 AD when Dr. Harry Klinefelter, under the supervision of Dr. Fuller Albright at the Massachusetts General Hospital in Boston, published a report explaining the case of nine 6-foot-tall males.
Objective: The purpose of the present study was to determine the relationship between fertility effectiveness and mosaic Klinefelter syndrome.
Methodology: In our study, karyotyping was conducted for 20 patients with mosaic Klinefelter syndrome, and the percentage of Klinefelter cells containing 47 chromosomes relative to the total number of cells was calculated. The percentages of mosaicism patients ranged between 7.31% to 20.0%, and semen tests were conducted after abstaining from sexual intercourse for 72 hours and not taking stimulant drugs for a one month), and the characteristics of the semen were examined such as motility, total number, acidity, and liquefaction, In a sister chromatid exchange experiment for patients with mosaic `Klinefelter syndrome, the number of exchanges per 50 cells was counted and compared with the count of the control group.
Results: Sample No. 1 was the most effective study group for semen, for which the percentage of mosaicism was 7.31%, and sample No. 20 was the least effective study group for semen. Sample No. 20, for which the percentage of mosaicism was 20%, indicated that the greater the percentage of mosaicism was small, the greater the effectiveness was, and the greater the percentage was, the lower the effectiveness was, which indicated that the percentage had a significant impact on the sexual activity of the individual. There are significant differences in sister chromatids exchanges between the group of mosaicism patients (67.22±4.17
exchange/50 cells) and the control group (56.11±2.4 exchange/50 cells).
Conclusion: There was a relationship between the percentage of mosaicism and the frequency of fertilization, as well as between the percentage of male sex hormones and the percentage of An increase in the components of semen, and thus an increase in the rate of fertilization of the ovum, sister chromatids exchanges is increased in patients compared to the control group.
Bangladesh Journal of Infectious Diseases, June 2026;13(1):208-214
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Copyright (c) 2026 Qutaiba Hommadi Al-Samarraie
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