Clinical Profile, Laboratory Findings and Outcome of Severe Dengue Infection among Children Admitted at a Tertiary Care Hospital in Bangladesh
DOI:
https://doi.org/10.3329/bjid.v9i2.67884Keywords:
Dengue fever, clinical profile, severe dengue infectionAbstract
Background: Dengue infection is endemic in Bangladesh and presents with varying degrees of severity of illness in children.
Objective: The purpose of the present study was to assess the common clinical profile, biochemical findings and outcome of severe dengue fever in children.
Methodology: This prospective cohot study was conducted on dengue NS1 or IgM or RT-PCR positive admitted children up to 14 years of age from April 2019 to October 2019 for a period of 6 months at the Pediatrics Department of Evercare Hospital, Dhaka. Data were analyzed after collection of demographic variables, presenting complaints and examination findings of 75 enrolled children.
Results: A total of 75 cases were classified as severe dengue fever. The most common age of presentation was 4 to 7 years. The most common presenting symptom of severe dengue cases were fever (97.3%), abdominal pain and vomiting (77.3%) and shock (62.7%). Pleural effusion was the most common physical findings seen in 35 cases (46.6%) followed by ascites in 26 cases (34.7%). Elevation in aspartate amino transaminase AST (IU/L) was found in 82.6%, low albumin was found in 78.7% of the cases. Hypernatremia was the most common electrolyte abnormality found in 35 cases (46.7%). Regarding coagulation profile, raised D-dimer & low fibrinogen were found in 53 (70.7%) & 42 cases (56.0%) respectively. Activated partial thromboplastin time (aPTT) was prolonged in 37.3%. Case fatality rate (CFR) was 5.3%.
Conclusion: In conclusion, raised AST and D-dimer, low fibrinogen & albumin level as well as hyponatremia are significant laboratory findings indicating severity of the disease. Shock is a common presentation of severe dengue in children.
Bangladesh Journal of Infectious Diseases, December 2022;9(2):40-46
Downloads
19
29
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Jannatul Ferdous, M. Quamrul Hassan, Sabina Sultana, Nurun Naher, Mohammed Istiaque Hossain, Badrun Nessa, Laila Nurun Nahar, Farzana Nahid
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright
Copyright on any research article in the Bangladesh Journal of Infectious Diseases is retained by the author(s).
The authors grant the Bangladesh Infection Research Association a license to publish the article and identify itself as the original publisher.
Articles in the Bangladesh Journal of Infectious Diseases are Open Access articles published under the Creative Commons CC BY-NC License (https://creativecommons.org/licenses/by-nc/4.0/)
This license permits use, distribution and reproduction in any medium, provided the original work is properly cited, and it is not used for commercial purposes.