Effect of Fenugreek (Methi) on Cortical Thickness of the Thymus in Streptozotocin-Induced Diabetic Rats

Authors

  • DK Mondal Associate Professor, Department of Anatomy, Khulna Medical College
  • MMA Moinuddin Assistant Professor (c.c.), Department of Physiology, Khulna Medical College.
  • MM Saha Associate Professor (c.c.), Department of Pathology, Khulna Medical College
  • AM Khanom Lecturer in Anatomy, Khulna Medical College.
  • BMA Yousuf Professor, Department of Anatomy, Chittagong Medical College.
  • MSA Talukder Professor, Department of Anatomy, Shaheed Suhrawardy Medical College, Dhaka
  • S Ara Professor & Head, Department of Anatomy, Dhaka Medical College, Dhaka

DOI:

https://doi.org/10.3329/bja.v7i1.3017

Keywords:

Diabetes mellitus, Differential lymphocyte count, Fenugreek, Thymus

Abstract

Objective: To find out microscopically whether Trigonella foenumgraecum (fenugreek seeds/methi seeds) has got any preventive role against the lowering of cortical thickness of the thymic lobules in diabetes mellitus.
Design: An experimental study on Long Evans rats which were divided into three equal groups depending on their different shorts of dietary feeding and drug treatment.
Setting: Anatomy department of IPGMR (Institute of Post Graduate Medicine and Research) at present BSMMU (Bangabandhu Sheikh Mujib Medical University) and BIRDEM (Bangladesh Institute of Research and Rehabilitation in diabetes, Endocrine & Metabolic Disorders).
Subjects: Fifty eight healthy young Long Evans rats of either sex weighing 72 to 174gm aged between 50 to 60 days were used in this study.
Main outcome measures: Variation of cortical thickness of the thymic lobules in different groups of rat.
Result: Cortical thickness in the nondiabetic control group, which ranges from 30.17 to 36.99. and the mean was 34.83 ± 0.60. In diabetic control group the cortical thickness ranges from 17.78 to 26.46 and the mean was 21.85 ± 1 On the other hand, in the fenugreek- treated diabetic rats the cortical thickness ranges from 25.71 to 32.95 and mean cortical thickness was 30.49 ± 0.75.
Conclusion: Fenugreek showed a tendency of acting against lowering of the cortical thickness of the thymic lobule of Streptozotocin-induced diabetes mellitus. However, further investigations are recommended for establishing fenugreek as a safe, useful effective agent to preserve the cortical thickness improving the diabetic condition by acting as antidiabetogenic agent.

Key words: Diabetes mellitus, Differential lymphocyte count, Fenugreek, Thymus  

doi: 10.3329/bja.v7i1.3017

Bangladesh Journal of Anatomy January 2009, Vol. 7 No. 1 pp. 37-41

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How to Cite

Mondal, D., Moinuddin, M., Saha, M., Khanom, A., Yousuf, B., Talukder, M., & Ara, S. (2009). Effect of Fenugreek (Methi) on Cortical Thickness of the Thymus in Streptozotocin-Induced Diabetic Rats. Bangladesh Journal of Anatomy, 7(1), 37–41. https://doi.org/10.3329/bja.v7i1.3017

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