Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action


  • Barun Kanti Saha BCSIR Laboratories, Chittagong
  • Md. Nurul Huda Bhuiyan BCSIR Laboratories, Chittagong
  • Kishor Mazumder Department of Pharmacy, University of Science and Technology, Chittagong
  • K. M. Formuzul Haque BCSIR Laboratories, Chittagong




Diabetes, Hypoglycemic effect, Lagerstromia speciosa, Streptozotocin


The hypoglycemic effect of Lagerstroemia speciosa L. leaves hot water extract on chemically induced diabetes in rat was investigated. Experimental result showed that, streptozotocin significantly (p<0.001) elevated the normal blood sugar level whereas treatment with hot water extract depressed the streptozotocin-induced high blood sugar level about 43.2% as compare to diabetic controls. Treatment with hot water extract increased the activity of shunt enzyme glucose–6-phosphate dehydrogenase (33.8%) and glutathione level (31.3%) and depression of the activity of hepatic gluconeogenic enzymes glucose-6-phasphatase (31.6%) and fructose-1,6-bisphosphatase (27.4%). These studies thus strongly suggest that the hot water extract of L. speciosa leave attributed its prominent hypoglycemic activity on experimental diabetic rats through suppression of gluconeogenesis and stimulation of glucose oxidation using the pentose phosphate pathway.


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Author Biography

Md. Nurul Huda Bhuiyan, BCSIR Laboratories, Chittagong

Scientific officer


Baginiski ES, Foa PP, Zak B. Methods of enzymatic analysis. Bergmeyer HU (ed.). Vol. 2. New York, Academic Press, 1974, pp 876-80.

Fisher LJ, Hamberger SA. Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase and a metal chelator. Diabetes 1980; 29: 213-16.

Fujii S, Dale GL, Beutler E. Glutathione dependent protection against oxidative damage of the human red cell membrane. Blood. 1984; 63: 1096-1101.

Fukushima M, Matsuyama F, Ueda N, Egawa K, Takemoto J, Kajimoto Y et al. Effect of corosolic acid on postchallenge plasma glucose levels. Diabetic Res Clin Pract. 2006; 73: 174-77.

Hattori K, Sukenobu N, Sasaki T, Takasuga S, Hayashi T, Kasai R, Yamasaki, Hazeki O, Activation of insulin receptors by Lagerstromin. J Pharmacol Sci. 2003; 93: 69-73.

Judy WV, Hari SP, Stogsdilla WW, Judy JS, Naguib YMA, Passwater R. Antidiabetic activity of a standardized extract (GlucosolTM) from Lagerstroemia speciosa leaves in type II diabetics A dose dependence study. J Ethnopharmacol. 2003; 87: 115-17.

Kakuda T, Sakane I, Takihara T, Ozaki Y, Tkeuchi H and Kuroyanagi M. Hypoglycemic effect of Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem. 1996; 60: 204-08.

Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori M. Beneficial effects of antioxidants in diabetes: Possible protection of pancreatic ?-Cell against glucose toxicity. Diabetes 1999; 48: 2398-2406.

Klein G, Kim J, Himmeldirk K, Chen X. Anti-diabetes and anti-obesity activity of Lagerstroemia speciosa. eCAM. 2007; 4: 401-07.

Liu F, Kim J, Li Y, Liu X, Li J, Chem X. An Lagerstroemia speciosa L. has insuline like glucose uptake stimulatory arid adipocyte differentiation inhibitory activities in 3T3-L1 cells. J Nutr. 2001; 131: 2242-47.

Lohr GW, Waller HD. Methods in enzymatic analysis. Bergmeyer HU (ed.) Vol. 2. New York, Academic Press, 1974, pp 636- 42.

Loven D, Schedl H, Wilson H, Daabas TT, Stegink DL, Diekus M, Oberley LW. Effect of insulin and oral glutathione on glutathione levels and superoxide dismutase activities in organs of rats with streptozotocin-induced diabetes. Diabetes 1986; 35: 503-07.

Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193: 265-75.

McCord JM. Human disease, free radicals and the oxidant/antioxidant balance. Clin Biochem. 1993; 26: 351-57.

McGilvery RW. Methods Enzymol. 1955; 2: 543-46.

Meister A, Anderson ME. Glutathionase. Ann Rev Biochem. 1983; 52: 711-60.

Mishra Y, Khan MSY, Zafar R, Agarwal SS. Hypoglycemic activity of leaves of Lagerstroemia speciosa (L) Pers. Indian J Pharmacol. 1990; 22: 174-76.

Miura T, Ueda N, Yamada K, Fukushima M, Ishida T, Kaneko T et al. Antidiabetic effects of corosolic acid in KK-Ay diabetic mice. Biol Pharm Bull. 2006; 29: 585-87.

Oberley LW. Free radicals and diabetes. Free Radical Biol Med. 1988; 5: 113-24.

Saha BK, Mehjabeen A, Mannor K, Khan AKA, Rahman R. Effects of Coccinia indica in streptozotocin-induced diabetic rats: Partial restoration of tissue level of reduced glutathione. Dhaka Univ J Biol Sci. 1997; 6: 221-25.

Saha BK, Sarker AK, Ahmed K, Krishna B, Hossain ME. Effects of Lagerstroemia speciosa L. extracts on alloxan-induced diabetic rats. Hamdard Medicus. 2006; XLIX: 23-28.

Saha BK, Sarkar A, Basak R, Chatterjee M. 1?,25- dihydroxyvitamin D3 suppresses the effect of streptozotocin-induced diabetes during chemical rat liver carcinogenesis. Cell Biol Int. (London). 2001; 25: 227-37.

Shibib BA, Khan LA, Rahman R. Hypoglycemic activity of Coccinia indica and Momordica charantia in diabetic rats: Depression of the hepatic gluconeogenic enzymes glucose-6-phosphatease and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6- phosphate dehydrogenase. Biochem J. 1993; 292: 267-70.

Suzuki Y, Unno T, Ushitani M, Hayashi K, Kakuda T. Anti-obesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-AY mice. J Nutr Sci Vitaminol. (Tokyo) 1999; 45: 791-95.

Trinder P. Determination of blood glucose using oxidase-peroxidase system with non carcinogen chromogen, J Clin Pathol. 1969; 22: 158-61.

Unno T, Sakane I, Masumizu T, Kohno M, Kakuda T. Antioxidants activity of water extracts from Lagerstroemia speciosa leaves. Biosci Biotechnol Biochem. 1997; 61: 1772-74.

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How to Cite

Saha, B. K., M. N. H. Bhuiyan, K. Mazumder, and K. M. F. Haque. “Hypoglycemic Activity of Lagerstroemia Speciosa L. Extract on Streptozotocin-Induced Diabetic Rat: Underlying Mechanism of Action”. Bangladesh Journal of Pharmacology, vol. 4, no. 2, Apr. 2009, pp. 79-83, doi:10.3329/bjp.v4i2.1539.



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