Dissolution Profile of Ibuprofen Solid Dispersion Prepared with Cellulosic Polymers and Sugar by Fusion Method

  • Nadia Saffoon Marketing Strategy Department, Ziska Pharmaceuticals Ltd., Dhaka
  • Yeakuty Marzan Jhanker Department of Pharmacy, The University of Asia Pacific, Dhaka
  • Naz Hasan Huda Department of Pharmacy, Stamford University Bangladesh
Keywords: Ibuprofen, Solid dispersion, Fusion method, Dissolution rate.

Abstract

The purpose of this study was to prepare and characterize solid dispersions of the NSAID Ibuprofen with HPMC, HPC, icing sugar, dextrose, mannitol and lactose with the intention of improving its dissolution properties. The solid dispersions were prepared by the fusion method. Evaluation of the properties of the dispersions was performed using dissolution studies. The results obtained showed that the rate of dissolution of Ibuprofen was considerably improved when formulated in solid dispersions with HPMC and HPC. Solid dispersions with icing sugar, dextrose, mannitol and lactose showed drug retarding capability which may trigger more research in the intension of exploiting this feature to prepare sustained release dosage form.  

Key words: Ibuprofen; Solid dispersion; Fusion method; Dissolution rate.

DOI: http://dx.doi.org/10.3329/sjps.v4i1.8864

SJPS 2011; 4(1): 31-37

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How to Cite
Saffoon, N., Jhanker, Y., & Huda, N. (1). Dissolution Profile of Ibuprofen Solid Dispersion Prepared with Cellulosic Polymers and Sugar by Fusion Method. Stamford Journal of Pharmaceutical Sciences, 4(1), 31-37. https://doi.org/10.3329/sjps.v4i1.8864
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Research Articles