Formulation Development of Verapamil Hydrochloride Tablet by Effervescent Method

Authors

  • Abul Kalam Lutful Kabir Lecturer, Dept. of Pharmacy, Jagannath University, Dhaka
  • Naz Hasan Huda Department of Pharmacy, Stamford University Bangladesh, Dhaka
  • Yeakuty Marzan Jhanker Department of Pharmacy, The University of Asia Pacific Dhaka
  • Kamrunnahar Shamin Department of Pharmacy, Stamford University Bangladesh, Dhaka

DOI:

https://doi.org/10.3329/sjps.v3i1.6795

Keywords:

Effervescent method, Verapamil Hydrochloride, Dispersion time

Abstract

Fast disintegrating tablets of Verapamil Hydrochloride were designed to achieve increased absorption as well as quick onset of pharmacological action of the active ingredient with a view to enhance patient compliance by effervescent method. Different combinations and ratios of sodium bicarbonate, anhydrous citric acid, sodium starch glycolate, Micro-crystalline cellulose (MCC) and lactose were used in order to get optimum result. The prepared formulations were evaluated for hardness, friability, thickness, diameter, taste of the solution to be administered and in-vitro dispersion time. The acceptable dispersion time was achieved by using a combination of citric acid and sodium bi carbonate in the same amount along with sodium starch glycolate, micro-crystalline cellulose (MCC) & lactose. Acceptable taste of the solution to be administered was obtained with a combination of sucrose, aspartame and sodium saccharine.

Key words: Effervescent method; Verapamil Hydrochloride; Dispersion time

DOI: 10.3329/sjps.v3i1.6795

S. J. Pharm. Sci. 3(1): 34-37

Downloads

Download data is not yet available.
Abstract
1018
PDF
907

Downloads

How to Cite

Kabir, A. K. L., Huda, N. H., Jhanker, Y. M., & Shamin, K. (2011). Formulation Development of Verapamil Hydrochloride Tablet by Effervescent Method. Stamford Journal of Pharmaceutical Sciences, 3(1), 34–37. https://doi.org/10.3329/sjps.v3i1.6795

Issue

Vol. 3 No. 1 (2010)

Section

Research Articles

License

As a condition of publication, all authors must transfer copyright to the Department of Pharmacy. Manuscripts submitted under multiple authorship are reviewed on the assumption that all listed authors concur in the submission, and that the final version of the manuscript has been seen and approved by them.

Each author must agree to this statement

Authorship: This manuscript is the original work of the authors, each of whom has read and approved of the work. Each author satisfied the requirements contained in 'Author Guidelines' having participated sufficiently in the work to take public responsibility for the content. This participation includes:

  • Conception or design of the study, or analysis and interpretation of data, or both
  • Drafting the article or revising it for critically important intellectual content
  • Approval of the final 'to be published' version

All authors must take responsibility for the integrity of the work. Participating solely in the collection of data does not justify authorship.

Prior publication: This work is not currently under consideration by any other journal. Information about prior publication of any part of this work, or inclusion of patients detailed herein in any other work, has been provided in the cover letter.

Conflict of interest: Details of any financial or other relationship between any author and any other party that may lead to a conflict of interest with the subject or any materials mentioned in this article have been disclosed in the cover letter.