Estimation of Manganese, Zinc and Copper in Multimineral Preparation Containing Vitamins: A Complexometric Approach
AbstractA simple, precise, complexometric titration method has been developed for the estimation of essential trace
metals- manganese, zinc and copper, in marketed multimineral pharmaceutical dosage form containing
vitamins. The selectivity of the method is accomplished by masking the minerals with suitable masking agent
(NaCN) and determining the metal ion using Complexon III (EDTA). The method having high recovery range
has successfully been applied for the determination of these trace metals in presence of other minerals and
vitamins. The values of different statistical parameters (e.g., standard deviation, coefficient of variation,
standard error, confidence interval) were also determined, which reflect the accuracy and validity of the
Key words: Multimineral; complexometric titration; Na2EDTA.
Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 16-20
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