Synthesis, anticonvulsant activity and <i>in silico</i> study of some novel amino acids incorporated bicyclo compounds

  • Chandra Shekhar Sharma Department of Pharmaceutical Chemistry, B. N. College of Pharmacy, Udaipur
  • Rajesh Kumar Nema Department of Pharmaceutical Chemistry, B. N. College of Pharmacy, Udaipur
  • Vinod Kumar Sharma Department of Chemistry, M. L. S. University, Udaipur
Keywords: Maximal electrical shock method, anticonvulsant activity, in silico toxicity

Abstract

In  the present study, some novel amino acids incorporated bicyclo compounds have been synthesized and
their structure was confirmed by physico-chemical and spectral data. The title compounds were evaluated for
in silico toxicity study and anticonvulsant activity by maximal electric shock method. The results showed that
substitution with cysteine and glutamic acid moiety was found to increase the activity. In silico toxicity study
results showed that the compounds are free of toxicity in neurotoxicity, irritability, sensitivity, immunotoxicity
and oncogenecity
 
Key words: Maximal electrical shock method; anticonvulsant activity; in silico toxicity.

DOI: 10.3329/sjps.v2i2.2607

Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 42-47

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Author Biography

Chandra Shekhar Sharma, Department of Pharmaceutical Chemistry, B. N. College of Pharmacy, Udaipur

Asst. Professor

Department of Pharm. Chemistry

Published
2010-08-12
How to Cite
Sharma, C., Nema, R., & Sharma, V. (2010). Synthesis, anticonvulsant activity and <i>in silico</i&gt; study of some novel amino acids incorporated bicyclo compounds. Stamford Journal of Pharmaceutical Sciences, 2(2), 42-47. https://doi.org/10.3329/sjps.v2i2.2607
Section
Research Articles