Synthesis, anticonvulsant activity and <i>in silico</i> study of some novel amino acids incorporated bicyclo compounds

Authors

  • Chandra Shekhar Sharma Department of Pharmaceutical Chemistry, B. N. College of Pharmacy, Udaipur
  • Rajesh Kumar Nema Department of Pharmaceutical Chemistry, B. N. College of Pharmacy, Udaipur
  • Vinod Kumar Sharma Department of Chemistry, M. L. S. University, Udaipur

DOI:

https://doi.org/10.3329/sjps.v2i2.2607

Keywords:

Maximal electrical shock method, anticonvulsant activity, in silico toxicity

Abstract

In  the present study, some novel amino acids incorporated bicyclo compounds have been synthesized and
their structure was confirmed by physico-chemical and spectral data. The title compounds were evaluated for
in silico toxicity study and anticonvulsant activity by maximal electric shock method. The results showed that
substitution with cysteine and glutamic acid moiety was found to increase the activity. In silico toxicity study
results showed that the compounds are free of toxicity in neurotoxicity, irritability, sensitivity, immunotoxicity
and oncogenecity
 
Key words: Maximal electrical shock method; anticonvulsant activity; in silico toxicity.

DOI: 10.3329/sjps.v2i2.2607

Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 42-47

Downloads

Download data is not yet available.
Abstract
1614
PDF
2059

Author Biography

Chandra Shekhar Sharma, Department of Pharmaceutical Chemistry, B. N. College of Pharmacy, Udaipur

Asst. Professor

Department of Pharm. Chemistry

Downloads

Additional Files

Published

2010-08-12

How to Cite

Sharma, C. S., Nema, R. K., & Sharma, V. K. (2010). Synthesis, anticonvulsant activity and <i>in silico</i> study of some novel amino acids incorporated bicyclo compounds. Stamford Journal of Pharmaceutical Sciences, 2(2), 42–47. https://doi.org/10.3329/sjps.v2i2.2607

Issue

Vol. 2 No. 2 (2009)

Section

Research Articles

License

As a condition of publication, all authors must transfer copyright to the Department of Pharmacy. Manuscripts submitted under multiple authorship are reviewed on the assumption that all listed authors concur in the submission, and that the final version of the manuscript has been seen and approved by them.

Each author must agree to this statement

Authorship: This manuscript is the original work of the authors, each of whom has read and approved of the work. Each author satisfied the requirements contained in 'Author Guidelines' having participated sufficiently in the work to take public responsibility for the content. This participation includes:

  • Conception or design of the study, or analysis and interpretation of data, or both
  • Drafting the article or revising it for critically important intellectual content
  • Approval of the final 'to be published' version

All authors must take responsibility for the integrity of the work. Participating solely in the collection of data does not justify authorship.

Prior publication: This work is not currently under consideration by any other journal. Information about prior publication of any part of this work, or inclusion of patients detailed herein in any other work, has been provided in the cover letter.

Conflict of interest: Details of any financial or other relationship between any author and any other party that may lead to a conflict of interest with the subject or any materials mentioned in this article have been disclosed in the cover letter.