Analgesic and Neuropharmacological Investigations of the Aerial Part of <i>Achyranthes aspera</i> Linn.
Analgesic and central nervous system depressant activity of the methanol extract of Achyranthes aspera Linn. was assessed by using acetic acid induced writhing test, thiopental sodium induced sleeping time determination, hole cross test and open field test in albino mice. The extract (250 and 500mg/kg) showed a dose dependent inhibition of writhing response generation by acetic acid compared to reference drug diclofenac sodium (50mg/kg). Methanol (70%) extract of Achyranthes aspera (500 mg/kg) also produced rapid onset and maximized the duration of sleeping time when administered with thiopental sodium. The extract also decreased the motor activity and exploratory behavior of mice in hole cross and open field test. The overall experimental results suggest the analgesic and central nervous system depressant activity of the methanolic extract of Achyranthes aspera and justify its use in folkloric remedies.
Key Words: Achyranthes aspera, Analgesic activity, Central nervous system depressant activity.
S. J. Pharm. Sci. 1(1&2): 44-50
Each author must agree to this statement
Authorship: This manuscript is the original work of the authors, each of whom has read and approved of the work. Each author satisfied the requirements contained in 'Author Guidelines' having participated sufficiently in the work to take public responsibility for the content. This participation includes:
- Conception or design of the study, or analysis and interpretation of data, or both
- Drafting the article or revising it for critically important intellectual content
- Approval of the final 'to be published' version
All authors must take responsibility for the integrity of the work. Participating solely in the collection of data does not justify authorship.
Prior publication: This work is not currently under consideration by any other journal. Information about prior publication of any part of this work, or inclusion of patients detailed herein in any other work, has been provided in the cover letter.
Conflict of interest: Details of any financial or other relationship between any author and any other party that may lead to a conflict of interest with the subject or any materials mentioned in this article have been disclosed in the cover letter.