Formulation development and characterization of fast disintegrating tablets of Nimesulide

  • Manoj M Nitalikar Department of Pharmaceutics, Shri Vithal Education and Research Institute?s College of Pharmacy, Pandharpur Dist., Solapur
  • Dinesh M Sakarkar Department of Pharmaceutics, S. N. Institute of Pharmacy, Pusad Dist., Yavatmal,
Keywords: Formulation, characterization, fast disintegrating, tablet, nimesulide

Abstract

An attempt was made to prepare fast dissolving tablets of anti-inflammatory drug Nimesulide preparing by direct compression method. The superdisintegrants Cross-carmellose and Sodium starch glycolate were used in different concentrations. Twelve formulations using those superdisintegrants at different concentration levels were prepared to access their efficiency and critical concentration level. Different evaluation parameters for tablet were studied. Tablets containing Cross-carmellose showed superior organoleptic properties and excellent in-vitro drug release as compared to other formulations. It was observed that on increasing the concentration of Cross-carmellose, the rate of disintegration was increased whereas on increasing the concentration of Sodium starch glycolate the rate of disintegration was decreased. The percentage drug release was observed as 96.32% when the concentration of Cross-carmellose was increased, whereas the same was not observed on increasing the concentration of Sodium starch glycolate.

DOI: http://dx.doi.org/10.3329/sjps.v4i2.10436

S. J. Pharm. Sci. 4(2) 2011: 25-28

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Abstract
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Published
2012-04-21
How to Cite
Nitalikar, M., & Sakarkar, D. (2012). Formulation development and characterization of fast disintegrating tablets of Nimesulide. Stamford Journal of Pharmaceutical Sciences, 4(2), 25-28. https://doi.org/10.3329/sjps.v4i2.10436
Section
Research Articles