Antidiabetic effect of bitter melon/Kerala (Momordica charantia) in alloxan induced diabetic rat

  • Rupaly Akhter Department of Pharmacology and Toxicology, Faculty of Animal Science and Veterinary Medicine, Sher-e-Bangla Agricultural University, Dhaka-1207
  • Imrul Hasan Rasel Adjunct Faculty, Faculty of Animal Science and Veterinary Medicine, Sher-e-Bangla Agricultural University, Dhaka-1207
  • Mohammad Saiful Islam Department of Anatomy, Histology and Physiology, Faculty of Animal Science and Veterinary Medicine, Sher-e-Bangla Agricultural University, Dhaka-1207
Keywords: Bitter melon, Diabetes, Alloxan, Blood glucose, Blood cholesterol, HDLC and LDLC, Triglyceride

Abstract

This study aims at investigating the effect of Momordica charantia extract on glucose tolerance and some biochemical parameters in alloxan induced diabetes rat. A total of 150 rats (50 normal rats and 100 alloxan induced diabetic rats) were used for five trials. The rats were divided into three groups for each trial, each containing 10 individuals as follows: Group A: is the control group, Group B as diabetic control group and group C were diabetic rat received bitter melon (Momordica charantia). Then alloxan injection was injected at a dose rate of 150 mg/kg body weight through intra-peritoneal route to each rat to induce diabetes in groups B and C. Aqueous extract of bitter melon (Momordica charantia) were fed by gavage at a dose of 300 mg/kg body weight daily for 21 days in group C. On 15th day blood glucose level and the body weights, biochemical parameters were measured for the first time to ensure diabetic induction. Then all the rats of this group were kept for more 21 days for the treatment of diabetic condition. Alloxan produced a significant increase in serum glucose, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), Alanine aminotransaminase (ALT) and Aspartate aminotransaminase (AST) and significant decrease in body weight and high density lipoprotein cholesterol (HDLC). Bitter melon treatment reduced non-fasting and fasting glucose level (p<0.05). In addition, administration of bitter melon juice was associated with a reduction in the serum levels of Alanine aminotransaminase (ALT) and Aspartate aminotransaminase (AST), Triglyceride (TG), Total Cholesterol (TC) and Low Density Lipoprotein Cholesterol (LDL-C) when compared with positive diabetic control (p<0.05). High density lipoprotein cholesterol (HDLC) and body weight level significantly increased in bitter melon treated group C compare to Group B (p<0.05).

Res. Agric., Livest. Fish.5(3): 373-379, December 2018

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Author Biographies

Rupaly Akhter, Department of Pharmacology and Toxicology, Faculty of Animal Science and Veterinary Medicine, Sher-e-Bangla Agricultural University, Dhaka-1207

Department of Pharmacology and Toxicology

Imrul Hasan Rasel, Adjunct Faculty, Faculty of Animal Science and Veterinary Medicine, Sher-e-Bangla Agricultural University, Dhaka-1207

Faculty of Animal Science and Veterinary Medicine

Mohammad Saiful Islam, Department of Anatomy, Histology and Physiology, Faculty of Animal Science and Veterinary Medicine, Sher-e-Bangla Agricultural University, Dhaka-1207

Department of Anatomy

Published
2018-12-31
How to Cite
Akhter, R., Rasel, I., & Islam, M. S. (2018). Antidiabetic effect of bitter melon/Kerala (Momordica charantia) in alloxan induced diabetic rat. Research in Agriculture Livestock and Fisheries, 5(3), 373-379. https://doi.org/10.3329/ralf.v5i3.39586
Section
Livestock