Plasma Fibrinogen and Fibrin Degradation Product (FDP) in Preeclampsia

  • Sharmin Sultana Assistant Professor, Department of Physiology Ad-din Sakina Medical College, Jessore
  • Susmita Nargis Assistant Professor, Department of Biochemistry Ad-din Sakina Medical College, Jessore
  • Heera Lal Roy Assistant Professor, Department of Biochemistry Khulna City Medical College, Khulna
  • Qazi Shamima Akhter Professor, Department of Physiology Dhaka Medical College, Dhaka
  • Rukhsana Afroz Assistant Professor, Department of Physiology Bikrampur Bhuiyan Medical College, Munshiganj, Dhaka
Keywords: Preeclampsia, Plasma fibrinogen, Fibrin degradation product

Abstract

Introduction: Hypercoagulable state is seen in preeclampsia which acts as a risk factor for thromboembolism & DIC. Altered coagulation indices (serum Fibrinogen & FDP) have been reported in patients with preeclampsia and have been suggested as a sensitive marker for detection of bleeding complications. This study was carried out to compare the coagulation indices in preeclamptic women.

Materials & Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College (DMC), Dhaka from January to December 2014. Total 100 women aged 18 – 40 years were selected from the department of Obstetrics & Gynaecology of DMCH, Dhaka for this study. Among them 50 were preeclamptic and age matched 50 healthy nonpregnant women were considered as control group. Fibrinogen & Fibrin Degradation Product (FDP) were analyzed on automated coagulation analyzer.

Result: In this study, serum Fibrinogen & FDP were significantly higher in preeclamptic than those of healthy women. Moreover, 100% & 64% preeclamptic patient had raised serum Fibrinogen & FDP respectively.

Conclusion: From this study it can be concluded that serum Fibrinogen & FDP are directly related with preeclampsia.

Medicine Today 2019 Vol.31(1): 36-38

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Abstract
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Published
2019-02-20
How to Cite
Sultana, S., Nargis, S., Roy, H., Akhter, Q., & Afroz, R. (2019). Plasma Fibrinogen and Fibrin Degradation Product (FDP) in Preeclampsia. Medicine Today, 31(1), 36-38. https://doi.org/10.3329/medtoday.v31i1.40320
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Original Articles