Comparative Efficacy of Topical Calcipotriol (0.005%) Versus Topical Corticosteroid (Betamethasone 0.1%) in Treating Plaque Type Psoriasis

Authors

  • Gulam Kazem Ali Ahmed Specialist in Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Lubna Khandker Assistant Professor, Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Moriom Nessa Assistant Professor, Department of Dermatology & Venereology, Islami Bank Medical College Hospital, Rajshahi
  • Mohd Nurul Alam Specialist in Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Anjana Chakraborty Specialist in Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Farhana Yeasmin Lecturer, Department of Pathology, Islami Bank Medical College Hospital, Rajshahi

DOI:

https://doi.org/10.3329/medtoday.v26i2.24228

Keywords:

Efficacy of calcipotriol, efficacy of corticosteroid (betamethasone), plaque type psoriasis

Abstract

A clinical trial was carried out to compare the efficacy of topical calcipotriol (0.005%) and topical corticosteroid (betamethasone 0.1%) in the treatment of plaque type psoriasis. The study was conducted from January 2012 to August 2012 and patients of plaque type psoriasis attending outpatient department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka were the study population. Patients were divided into two groups, group A was treated with topical calcipotriol (0.005%) ointment and group B with topical corticosteroid (betamethasone 0.1%) ointment. The mean baseline PASI score was 6.7 ±4.5 and after 8 weeks, the mean PASI score was 2.0 ±1.4 for group A and mean baseline PASI score was 5.5 ±4.2 and after 8 weeks, the mean PASI score was 2.5 ±1.4 for group B. There was statistically significant reduction in PASI score from base line after 8 weeks of treatment in both treatment groups (p < 0.001). After 8th week of treatment moderate response was 11(73.3%) in group A and 9(60%) in group B. Very good response was 4 (26.7%) in group B and 2 (13.3%) in group A and minimal response of treatment occurs equally 2 (13.3%) in group A and group B. In the light of the findings of the study we conclude that each of the treatment of calcipotriol(0.005%) and betamethasone (0.1%) is individually effective. Further multicenter, randomized, double-blind study should be conducted with large sample size.

Medicine Today 2014 Vol.26(2): 88-94

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Author Biography

Gulam Kazem Ali Ahmed, Specialist in Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka



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Published

2015-07-16

How to Cite

Ahmed, G. K. A., Khandker, L., Nessa, M., Alam, M. N., Chakraborty, A., & Yeasmin, F. (2015). Comparative Efficacy of Topical Calcipotriol (0.005%) Versus Topical Corticosteroid (Betamethasone 0.1%) in Treating Plaque Type Psoriasis. Medicine Today, 26(2), 88–94. https://doi.org/10.3329/medtoday.v26i2.24228

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