Eco-friendly Syntheses of Bioactive Iodoflavone from Chalcone under Microwave Condition for the Screening of Their Antibacterial Activity
Keywords:Iodoflavones; Chalcone; Flavonoid; Microwave Irradiation; Antibacterial activity
Flavonoids possess potent biological activity due to the presence of heterocyclic ring moiety and have been established as one of the biologically important scaffolds. Iodinated-flavones were synthesized from corresponding chalcones. Both conventional and microwave techniques were used to synthesize these compounds to make a comparative study. A significant reduction in reaction time and increase in % yield has been observed in the microwave technique. Spectroscopic techniques such as UV, IR, and NMR have been used to confirm the structures of all compounds. Agar disk diffusion method was employed to evaluate the antibacterial activities of the newly synthesized compounds against some bacterial strains such as Salmonella typhi, Streptococcus spp, Shigella spp. etc. Iodoflavone was found to be higher potency against most the bacteria, while others were moderately active.
J. of Sci. and Tech. Res. 3(1): 69-76, 2021
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Copyright (c) 2021 MM Hossain, S Khan, M Mohsin, MM Sarker, SM Rahaman
This work is licensed under a Creative Commons Attribution 4.0 International License.