Monitoring Antimicrobial Susceptibility of <i>Neisseria gonorrhoeae</i> Isolated from Bangladesh during 1997-2006: Emergence and Pattern of Drug-resistant Isolates

Authors

  • Monir Uddin Ahmed Laboratory Sciences Division, ICDDR,B, Dhaka and Institute of Food and Radiation Biology
  • Faisal Arif Hasan Chawdhury Laboratory Sciences Division, ICDDR,B, Dhaka and Department of Medical Microbiology, University of Manitoba, Winnipeg
  • Maqsud Hossain Laboratory Sciences Division, ICDDR,B, Dhaka and Department of Life Sciences, North South University, Dhaka
  • Syed Zafar Sultan Laboratory Sciences Division, ICDDR,B, Dhaka and Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta
  • Mansur Alam Laboratory Sciences Division, ICDDR,B, Dhaka
  • Gazi Salahuddin Laboratory Sciences Division, ICDDR,B, Dhaka
  • Ashraful Alam M.A.G. Osmani Medical College, Sylhet
  • Khairun Nessa Laboratory Sciences Division, ICDDR,B, Dhaka
  • Shamsun Nahar Laboratory Sciences Division, ICDDR,B, Dhaka
  • Shama A-Waris Laboratory Sciences Division, ICDDR,B, Dhaka
  • Anadil Alam Laboratory Sciences Division, ICDDR,B, Dhaka
  • Motiur Rahman Laboratory Sciences Division, ICDDR,B, Dhaka and 7Laboratory Sciences Division, Family Health International, Asia Pacific Regional Office, Bangkok

DOI:

https://doi.org/10.3329/jhpn.v28i5.6152

Keywords:

Drug resistance, Microbial, Gonorrhoea, Neisseria gonorrhoeae, Sexually transmitted infections, Surveillance, Bangladesh

Abstract

Gonorrhoea is one of the most common sexually transmitted infections (STIs) in developing countries, and the emergence of resistance to antimicrobial agents in Neisseria gonorrhoeae is a major obstacle in the control of gonorrhoea. Periodical monitoring of antimicrobial susceptibility of N. gonorrhoeae is essential for the early detection of emergence of drug resistance. In total, 1,767 gonococcal strains isolated from males and females (general population and those with high-risk behaviour) from different parts of Bangladesh were studied during 1997-2006. Minimum inhibitory concentrations of penicillin, tetracycline, ciprofloxacin, ceftriaxone, spectinomycin, and azithromycin for the isolates were determined by the agar dilution method. Isolates resistant to three or more antimicrobial agents are considered multidrug-resistant. The prevalence of plasmid-mediated penicillinase-producing N. gonorrhoeae (PPNG) and plasmid-mediated tetracycline-resistant N. gonorrhoeae (TRNG) was determined. Nine percent of the isolates were resistant to ciprofloxacin in 1997 compared to 87% in 2006. Multidrug-resistant N. gonorrhoeae have emerged in 1997, and 44% of the strains (n=66) isolated during 2006 were multidrug-resistant. Forty-two percent of the isolates in 2006 were both PPNG- and TRNG-positive compared to none in 1997. The rapidly-changing pattern of gonococcal antimicrobial susceptibility warrants the need for an antimicrobial susceptibilitymonitoring programme, and periodical analysis and dissemination of susceptibility data are essential to guide clinicians and for successful STI/HIV intervention programmes.

Key words: Drug resistance, Microbial; Gonorrhoea; Neisseria gonorrhoeae; Sexually transmitted infections; Surveillance; Bangladesh

DOI: 10.3329/jhpn.v28i5.6152

J HEALTH POPUL NUTR 2010 Oct;28(5):443-449

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How to Cite

Ahmed, M. U., Chawdhury, F. A. H., Hossain, M., Sultan, S. Z., Alam, M., Salahuddin, G., Alam, A., Nessa, K., Nahar, S., A-Waris, S., Alam, A., & Rahman, M. (2010). Monitoring Antimicrobial Susceptibility of <i>Neisseria gonorrhoeae</i> Isolated from Bangladesh during 1997-2006: Emergence and Pattern of Drug-resistant Isolates. Journal of Health, Population and Nutrition, 28(5), 443–449. https://doi.org/10.3329/jhpn.v28i5.6152

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