Ampicillin and Gentamicin Are a Useful First-line Combination for the Management of Sepsis in Under-five Children at an Urban Hospital in Bangladesh

Authors

  • Samira Bibi Pharmacy Department, East West University, Dhaka
  • Mohammod Jobayer Chisti Dhaka Hospital and Centre for Nutrition and Food Security (CNFS), icddr,b, GPO Box 128, Dhaka 1000
  • Farhana Akram Pharmacy Department, East West University, Dhaka
  • Mark AC Pietroni Dhaka Hospital,Dhaka 1000

DOI:

https://doi.org/10.3329/jhpn.v30i4.13418

Keywords:

Antibiotics, Children, Diarrhoea, Infant, Sepsis, Bangladesh

Abstract

The study evaluated the commonly-used drugs for the management of sepsis and their outcome among under-five children. We evaluated the hospital-records of all paediatric sepsis patients (n= 183) in the intensive care unit (ICU) and longer-stay unit (LSU) of the Dhaka Hospital of icddr,b. These records were collected from the hospital management system (SHEBA) during November 2009 to October 2010. A total of 183 under-five children with clinical sepsis were found during the study period, and 14 (8%) of them were neonates. One hundred and eighty-one patients had received a combination of injection ampicilin and injection gentamicin, and two patients had received the combination of injection ceftriaxone and injection gentamicin. Only 46 (25%) patients required a change of antibiotics to the combination of intravenous ceftriaxone plus gentamicin after non-response of injection ampicilin and injection gentamicin combination; 7/181 (4%) patients died who received injection ampicilin and injection gentamicin whereas none died among the other two patients who received injection ceftriaxone and injection gentamicin (p=1.00). The combination of injection ampicilin and injection gentamicin as the first-line antibiotics for the management of sepsis in children even beyond the neonatal age is very effective, resulting in lower mortality.

DOI: http://dx.doi.org/10.3329/jhpn.v30i4.13418

J HEALTH POPUL NUTR 2012 Dec;30(4):487-490

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Published

2013-01-19

How to Cite

Bibi, S., Chisti, M. J., Akram, F., & Pietroni, M. A. (2013). Ampicillin and Gentamicin Are a Useful First-line Combination for the Management of Sepsis in Under-five Children at an Urban Hospital in Bangladesh. Journal of Health, Population and Nutrition, 30(4), 487–490. https://doi.org/10.3329/jhpn.v30i4.13418

Issue

Section

Short Report