Effect of Cinnamon (Cinnamomum cassia) as a Lipid Lowering Agent on Hypercholesterolemic Rats

  • Sonia Rahman Department of Pharmacology and Therapeutics, Sir Salimullah Medical College, Dhaka
  • Halima Begum Department of Pharmacology and Therapeutics, Enam Medical College, Savar, Dhaka
  • Zaida Rahman Department of Pharmacology and Therapeutics, Enam Medical College, Savar, Dhaka
  • Ferdous Ara Department of Pharmacology and Therapeutics, Sir Salimullah Medical College, Dhaka
  • Md. Jalaluddin Iqbal Department of Pharmacology and Therapeutics, Sir Salimullah Medical College, Dhaka
  • Abul Kalam Mohammad Yousuf Department of Pharmacology and Therapeutics, Northern International Medical College, Dhanmondi, Dhaka
Keywords: Cinnamomum cassia, Dyslipidemia, Hypercholesterolemic rats

Abstract

Background: Dyslipidemia is one of the important causes of cardiovascular disease related mortality and morbidity. Recently it has become a significant issue in public health problem of developing countries. The purpose of the study was to find a suitable solution for reducing blood lipid in dyslipidemic patients by conducting a research on the effect of cinnamon in hypercholesterolemic rats.

Objective: To study the lipid lowering effect of Cinnamomum cassia on experimentally induced hypercholesterolemic rats.

Materials and Methods: This study was done on 30 male Long Evans rats weighing about 200--210 gram. For convenience, the study was divided into two experiments --- Experiment I and Experiment II. In experiment I, 12 animals were divided into two groups. One was Group A (n = 6, control group) fed on laboratory diet and the other was Group B (n = 6) fed on laboratory diet and cinnamon for 35 days. In experiment II, the remaining 18 rats were fed fatty mixture diet containing 1% cholesterol and 0.25% cholic acid. The hypercholesterolemic rats were then divided into 3 groups, Group C, D, and E (n=6 in each group). Group D and Group E were additionally fed on cinnamon powder and tablet atorvastatin for 35 days respectively. Serum TC, TG, LDL-C and HDL-C were measured after 35 days.

Results: Fatty mixture diet increased TG, TC and LDL-C significantly. Cinnamon treated fatty mixture diet group showed that Cinnamomum cassia decreased plasma TC, TG and LDL-C. Atorvastatin therapy decreased TC, TG and LDL-C levels significantly compared with the lowering effect of cinnamon.

Conclusion: The results of this experimental study indicate that Cinnamomum cassia can act as a hypocholesterolemic agent and thereby can improve cardiovascular functions.

Journal of Enam Medical College; Vol 3 No 2 July 2013; Page 94-98

DOI: http://dx.doi.org/10.3329/jemc.v3i2.16132

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Abstract
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Published
2013-08-07
How to Cite
Rahman, S., Begum, H., Rahman, Z., Ara, F., Iqbal, M., & Yousuf, A. (2013). Effect of Cinnamon (Cinnamomum cassia) as a Lipid Lowering Agent on Hypercholesterolemic Rats. Journal of Enam Medical College, 3(2), 94-98. https://doi.org/10.3329/jemc.v3i2.16132
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Original Articles