Raised Vaginal Fluid Fibronectin Level Indicates Premature Rupture of Membrane

  • Shamima Rahman Junior Consultant, Department of Gynaecology and Obstetrics, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Samsad Jahan Associate Professor, Department of Gynaecology and Obstetrics, Ibrahim Medical College, Dhaka
  • Samira Humaira Habib Senior Research Officer, Health Economics Unit, Bangladesh Diabetic Somity, Dhaka
  • Nasrin Sultana Junior Consultant, Department of Gynaecology and Obstetrics, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Mst Nigar Sultana Junior Consultant, Department of Gynaecology and Obstetrics, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Debashish Paul Research Fellow, Biomedical Research Group (BMRG), BIRDEM, Dhaka
  • Amrita Bhowmik Research Fellow, Biomedical Research Group (BMRG), BIRDEM, Dhaka
  • Khodeja Begum Consultant, Department of Gynaecology, National Institute of Cancer Research and Hospital (NICRH), Dhaka
Keywords: Vaginal fluid, Fibronectin, Rupture of membrane

Abstract

Background: Premature rupture of membrane (PROM) is one of the common complications  of pregnancy that has major impact on fetal and neonatal outcome. It is the commonest  clinical event where a normal pregnancy becomes suddenly a high-risk one for mother and  fetus or neonate.

Objective: The study was undertaken to investigate whether raised  fibronectin level in vaginal fluid may indicate premature rupture of membrane.

Materials and  Methods: This cross sectional study was conducted in the department of Obstetrics and  Gynecology in Sir Salimullah Medical College & Mitford Hospital, Dhaka during the period  of January 2006 to December 2007. A total of 114 pregnant women with gestational age 28th  week up to 40th week were included. Sixty were PROM (Group I) and 54 were non-PROM  (Group II) subjects. Fibronectin in vaginal fluid was measured by an immunochemical  reaction by nephelometer. Statistical analysis was done by SPSS version 10.0.

Results: The  PROM patients had significantly higher concentration of fibronectin (225.77 ± 115.18 ng/mL)  compared to that in non-PROM subjects (8.04 ± 16.17 ng/mL) (p < 0.001).

Conclusion: It  can be concluded that in cases of unequivocal rupture or intactness of the membranes, the  result of the fibronectin test corresponds well with the clinical situation. So fibronectin is a  sensitive test for detection of amniotic fluid in the vagina.

DOI: http://dx.doi.org/10.3329/jemc.v2i2.12841

J Enam Med Col 2012; 2(2): 74-79

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Abstract
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Published
2012-12-05
How to Cite
Rahman, S., Jahan, S., Habib, S., Sultana, N., Sultana, M., Paul, D., Bhowmik, A., & Begum, K. (2012). Raised Vaginal Fluid Fibronectin Level Indicates Premature Rupture of Membrane. Journal of Enam Medical College, 2(2), 74-79. https://doi.org/10.3329/jemc.v2i2.12841
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Original Articles