Comparison of 24 Hour Urinary Protein and Spot Urinary Protein- Creatinine Ratio in the Assessment of Proteinuria in Patients with Glomerulonephritis

Authors

  • Parvez Iftekhar Ahmed Assistant Professor, Department of Nephrology, Dhaka Medical College &Hospital, Dhaka
  • Md Nazrul Islam Associate Professor, Department of Nephrology, Dhaka Medical College & Hospital, Dhaka
  • Md Babrul Alam Assistant Professor, Department of Nephrology, National Institute of Kidney Diseases and Urology (NIKDU), Dhaka
  • Ferdous Kamal Bhuiya Assistant Professor, Department of Nephrology, Dhaka Medical College &Hospital, Dhaka
  • Mesbah Uddin Noman Consultant, Medicine, DGHS, Dhaka
  • Md Nizamuddin Chowdhury Professor and Head, Department of Nephrology, Dhaka Medical College & Hospital,Dhaka

DOI:

https://doi.org/10.3329/jdmc.v23i2.25390

Keywords:

Glomerulonephritis, 24 hour Urinary Total Protein, Urinary Protein Creatinine Ratio

Abstract

Context: Glomerulonephritis is an important cause of morbidity and mortality among all age group in Bangladesh. This cross sectional study was carried out with an aim to observe the comparison of 24 hour urinary protein and spot urinary protein- creatinine ratio in patients with glomerulonephritis in 3 group: on basis of 24 hour total protein, GFR level and serum albumin level.

Methods: A total number of 128 consecutive patients having glomerulonephritis with 18 to 70 years who came in the Nephrology Unit, Dhaka Medical College Hospital, Dhaka, during the period of January to December of 2011 were included in this study. Patients with proteinuria other than glomerulonephritis like DM, UTI and Hypertension and <18 years of age were excluded from the study.

Results: A significant positive correlation was found between 24 hour Urine Protein with Protein Creatinine Ratio on the patients having 24 hour Urinary protein <0.2 gm, 0.2-<1 gm, 1- 3.4 gm and 3.5-6 gm respectively. No correlation was found between 24 hr Urine Protein with Protein Creatinine Ratio on the patients having 24 hour Urinary protein >6 gm. A significant positive correlation was also found between 24 hour Urine Protein (gm/24 hour) with Protein Creatinine Ratio, which were in patients having GFR <15 ml/min/1.73m2 body surface area, 15-29 ml/min/1.73m2 body surface area, 30-59 ml/min/1.73m2 body surface area, 60-89 ml/ min/1.73m2 body surface area and e90 ml/min/1.73m2 body surface area respectively. However, the result of the group having GFR <15 ml/min/1.73m2 body surface was positively correlated but not very convincing. In this present series it was observed that a significant positive correlation was found between 24 hr Urine Protein (gm/24 hour) with Spot Urinary Protein Creatinine Ratio in relation to serum albumin level; r=0.658; (p<0.001) and r=0.707; (p<0.001) in patients having serum albumin level >30gm/dl and 20-30 gm/dl respectively. But because of only one sample in the group having <20 gm/dl serum albumin, no comparison could be carried out.

Conclusion: P/C ratio provided a very useful, simple and convenient method for quantitative assessment of protein and can replace 24 hour urine collection method in indoor, outpatients and in follow up clinics as it gives quick and reliable results and avoids the inconvenience and short comings associated with 24 hour urine collection.

J Dhaka Medical College, Vol. 23, No.2, October, 2014, Page 194-202

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Author Biography

Parvez Iftekhar Ahmed, Assistant Professor, Department of Nephrology, Dhaka Medical College &Hospital, Dhaka



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Published

2015-10-23

How to Cite

Ahmed, P. I., Islam, M. N., Alam, M. B., Bhuiya, F. K., Noman, M. U., & Chowdhury, M. N. (2015). Comparison of 24 Hour Urinary Protein and Spot Urinary Protein- Creatinine Ratio in the Assessment of Proteinuria in Patients with Glomerulonephritis. Journal of Dhaka Medical College, 23(2), 194–202. https://doi.org/10.3329/jdmc.v23i2.25390

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