Clinical, Laboratory and Neuroimaging of Acquired Demyelinating Syndrome of the Children Admitted in a Tertiary Care Hospital in Bangladesh

Authors

  • Jobaida Parvin Assistant Professor, Pediatric Neurology, National Institute of Neurosciences and Hospital, Dhaka, Bangladesh
  • Dipa Saha Associate Professor of Paediatric Neurology, Ad-din Women's Medical College, Moghbazar, Dhaka, Bangladesh
  • Husnea Ara Khan Assistant Professor of Paediatric Neurology and Development, National Institute of Neurosciences and Hospital (NINSH), Sher-E-Bangla Nagar, Agargaon, Dhaka, Bangladesh
  • Narayan Chandra Saha Professor, Department of Paediatric Neurology, National Institutes of Neuro-sciences (NINS), Sher-e-Bangla Nagar, Dhaka, Bangladesh
  • Mohammad Monir Hossain Assistant Professor, Department of Paediatric Neurology, National Institutes of Neuro-sciences (NINS), Sher-e-Bangla Nagar, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jbcps.v43i2.80808

Keywords:

Children, Acquired demyelinating disease, ADEM, NMOSD, ON

Abstract

Background: Acquired demyelinating syndrome (ADS) are autoimmune inflammatory disorder affecting the white matter of brain, optic nerve and spinal cord, and it has long been unrecognized. Early diagnosis and proper management slow the disease progression and reduce mortality and morbidity.

Objective: To find out the clinical, laboratory and neuroimaging patterns of ADS in children in Bangladesh.

Materials and Methods: A cross-sectional study was conducted from July 2020 to January 2021 in the Department of Pediatric Neurology, National Institute of Neuroscience and Hospital, including 37 children <18 years who had acute neurological deficits and MRI evidence of demyelination. After enrollment detailed history, physical examination, CSF study, oligoclonal bands (OCBs), and anti-NMO antibody was done and managed accordingly. Statistical analysis was done using SPSS version 22.

Result: The mean age was 8.79 ± 2.94 years, males were predominant. Most of the patients (24) had limb weakness (78.6%), headache (46.9%), altered consciousness (42.4%) and visual disturbance (39.4%). Monophasic ADEM (43%) followed by NMOSD (24%), TM (21%), ON (6%) and MS (6%) were common ADS. Common findings of brain imaging were bilateral (42.4%), multifocal (57.57%), juxtacortical (36.4%) and periventricular (24.2%) demyelinating lesions.

Conclusion: This study concluded that pediatric ADS had diverse clinical and radiological presentations, which were difficult to recognize for substantial clinical overlap.

J Bangladesh Coll Phys Surg 2025; 43: 134-138

Downloads

Abstract
20
PDF
10

Downloads

Published

2025-04-30

How to Cite

Parvin, J., Saha, D., Khan, H. A., Saha, N. C., & Hossain, M. M. (2025). Clinical, Laboratory and Neuroimaging of Acquired Demyelinating Syndrome of the Children Admitted in a Tertiary Care Hospital in Bangladesh. Journal of Bangladesh College of Physicians and Surgeons, 43(2), 134–138. https://doi.org/10.3329/jbcps.v43i2.80808

Issue

Vol. 43 No. 2 (2025)

Section

Original Articles

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Bangladesh College of Physicians and Surgeons and may not be reproduced by any means in whole or in part without the written consent of the publisher.

No part of the materials published in this journal may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher. Reprints of any article in the Journal will be available from the publisher.