Pseudotumorcerebri – a rare complication of ATRA based treatment of Acute Promyelocytic Leukaemia

Authors

  • Mohammad Golam Rabbani Professor and Head, Department of Haematology, Chittagong Medical College Hospital, Chattogram, Bangladesh
  • Nabina Lala Medical officer, Department of Haematology, Chittagong Medical College Hospital, Chattogram, Bangladesh
  • Showrab Biswas Registrar, Department of Haematology, Chittagong Medical College & Hospital, Chattogram, Bangladesh
  • S M Jashimuddin Clinical Pathologist, Chattogram Medical college and Hospital, Chattogram, Bangladesh
  • Md Ashequl Wahab Chowdhury Assistant Registrar, Department of Haematology, Chittagong Medical College & Hospital, Chattogram, Bangladesh

DOI:

https://doi.org/10.3329/jbcps.v42i1.70656

Keywords:

Acute promyelocytic leukemia; Pseudotumour cerebri; All trans retinoic acid

Abstract

Acute promyelocytic leukaemia is a highly curable sub type of acute myeloid leukaemia and about 90% of these patients have good chance of survival with current all transretinoic acid based arsenic tri oxide or chemotherapy. However, a rare complication, pseudotumour cerebri may arise following All Trans Retinoic Acid (ATRA) therapy, which may provide obstacle to continue this promising therapy. We present the case report of a young female patient with acute promyelocytic leukaemia treated with Arsenic trioxide (ATO) and ATRA that subsequently develop abrupt onset of lateral rectus palsy and decreased visual acuity due to pseudotumour cerebri. We treated the patient with acetazolamide and kept her at frequent follow up. There was significant improvement of her lateral rectus palsy as well as visual acuity following treatment with acetazolamide that allowed us to continue the primary All Trans Retinoic Acid (ATRA) based treatment.

J Bangladesh Coll Phys Surg 2024; 42: 105-108

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Published

2024-01-10

How to Cite

Rabbani, M. G., Lala, N., Biswas, S. ., Jashimuddin, S. M., & Chowdhury, M. A. W. (2024). Pseudotumorcerebri – a rare complication of ATRA based treatment of Acute Promyelocytic Leukaemia. Journal of Bangladesh College of Physicians and Surgeons, 42(1), 105–108. https://doi.org/10.3329/jbcps.v42i1.70656

Issue

Vol. 42 No. 1 (2024)

Section

Case Reports

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