Haematologic Profile Abnormalities and Coagulopathy Associated with Covid-19: A Prospective Study of 100 Patients
Keywords:ALC-Absolute lymphocyte count, ANC- Absolute neutrophil count, Coronavirus, COVID-19, D-dimer, SARSCOV- 2.
Background: The number of COVID-19 patients is exponentially increasing worldwide since December, 2019. Management in intensive care units (ICU) has become a major challenge; therefore, time demanding laboratory markers for early recognition of morbid forms is utmost important for timely triaging of patients.
Objective: The present study aimed to evaluate the role of haemotological and Coagulation profile in the assessment of disease severity of COVID-19. Methods: The current study is an observational study done prospectively in Armed Forces Institute of Pathology (AFIP) during the period of 28 March 2020 to 15 May 2020. The study subjects were haematological and coagulation profile data of 100 COVID-19 patients grouped in non-ICU and ICU at the baseline and at 4th day of admission in Combined Military Hospital (CMH), Dhaka. All the data were recorded and analyzed by SPSS 20.0 programme.
Results: Here subjects with featured of lymphopenia were detected prominently in our COVID-19 ICU patients with a median nadir ALC of 0.9 x109/L. The most common pattern of coagulopathy observed in patients hospitalized with COVID-19 is characterized by elevation in fibrinogen and Ddimer levels, particularly significantly higher in ICU group.
Conclusion: The present study is a reflection of significant anomalies in haematological and coagulation parameters during the disease process with COVID-19.
J Bangladesh Coll Phys Surg 2020; 38(0): 61-66
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