A Screening Test for Iron Deficiency Anaemia and Thalassaemia Traits

Authors

  • Amin Lutful Kabir Assistant Professor, Dept. of Hematology, BSMMU, Dhaka
  • Tashmim Farhana Dipta Associate Professor, Haematology and Dept. of Transfusion Medicine, BIRDEM and Ibrahim Medical College, Dhaka
  • Hajera Khatun Specialist, Square Hospital LTD
  • Mohammad Hafizur Rahman Head, Haematology unit, ICDDR,B, Dhaka
  • Mahfuz Haq Haematologist, Dept. of Haematology, AFIP and CMH, Dhaka
  • Mohammad Kazim Uddin Professor, Dept. of Pathology, Northern International Medical College, Dhaka
  • Masuda Begum Professor, Dept. of Hematology, BSMMU, Dhaka

DOI:

https://doi.org/10.3329/jbcps.v32i4.26063

Keywords:

NESTROF, IDA, Thalassaemia

Abstract

Both iron deficiency and thalassaemia trait can present with hypochromic microcytic morphology. Naked eye single tube red cell osmotic fragility (NESTROF) is an inexpensive and simple test which can effectively differentiate iron deficiency anaemia from thalassaemia trait. Our study was an opportunity to observe the role of NESTROF in screening of thalassaemia trait among our study population. Initially NESTROF was carried out in 677 patients (N) population of four groups having both positive and negative NESTORF; for economical issue, auto-analyzer study and haemoglobin electrophoresis were done among only 100 randomly selected subjects, who were finally included in our study as final study population (n). In our study, NESTROF was 94.23% sensitive and its specificity was 92.08%. The predictive value of a positive test was 88.13% and predictive value of a negative test was 96.24%. Our study showed, NESTROF can effectively differentiate iron deficiency anaemia (IDA) from thalassaemia trait but, is not effective in co-existent IDA and thalassaemia.

J Bangladesh Coll Phys Surg 2014; 32: 190-193

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Author Biography

Amin Lutful Kabir, Assistant Professor, Dept. of Hematology, BSMMU, Dhaka



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Published

2015-12-28

How to Cite

Kabir, A. L., Dipta, T. F., Khatun, H., Rahman, M. H., Haq, M., Uddin, M. K., & Begum, M. (2015). A Screening Test for Iron Deficiency Anaemia and Thalassaemia Traits. Journal of Bangladesh College of Physicians and Surgeons, 32(4), 190–193. https://doi.org/10.3329/jbcps.v32i4.26063

Issue

Vol. 32 No. 4 (2014)

Section

Original Articles

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