Non-HDL Cholesterol Versus LDL Cholesterol as a CVD Risk Factor in Diabetic Subjects

Authors

  • M Saiedullah Senior Lecturer, Department of Applied Laboratory Sciences, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh; Senior Scientific Officer, Department of Clinical Biochemistry, Bangladesh Institute of Health Sciences (BIHS), Dhaka
  • S Begum Lecturer, Department of Applied Laboratory Sciences, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh; Senior Scientific Officer, Department of Clinical Biochemistry, Bangladesh Institute of Health Sciences (BIHS), Dhaka,
  • S Hayat Lecturer, Department of Applied Laboratory Sciences, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh; Scientific Officer, Department of Clinical Biochemistry, Bangladesh Institute of Health Sciences (BIHS), Dhaka
  • SM Kamahuddin Lecturer, Department of Applied Laboratory Sciences, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh; Senior Scientific Officer, Department of Clinical Biochemistry, Bangladesh Institute of Health Sciences (BIHS), Dhaka
  • MR Rahman Associate Professor, Dept. of Biochemistry, Delta Medical College, Dhaka
  • MAH Khan Professor, Department of Biochemistry, Enam Medical College, Dhaka

DOI:

https://doi.org/10.3329/jbcps.v31i4.21004

Keywords:

CVD risk factors, Non-HDL cholesterol, LDL cholesterol, Diabetes mellitus

Abstract

Objective: Serum low density lipoprotein (LDL) cholesterol is considered as the primary target of lipid lowering therapy and non-high density lipoprotein (HDL) cholesterol is the recommended second target. Recent studies claimed that non-HDL cholesterol is a better predictor of cardiovascular diseases (CVD) than LDL cholesterol. In this study we aimed to compare non-HDL cholesterol and LDL cholesterol as a CVD risk factor in confirmed diabetic subjects.

Materials and methods: In this cross-sectional observational study, 1042 confirmed diabetic subjects selected randomly were included. HbA1c

Results: In the total subjects, 767 (74%) subjects had LDL cholesterol > 100 mg/dL and 822 (79%) subjects had non- HDL cholesterol > 130 mg/dL. HbA1c values were different (p<0.02) in five groups and showed upward trend (p<0.01). All the lipid parameters studied were significantly different in five groups (p<0.0001) and TC, TG and non-HDL cholesterol showed upward trend (p<0.0001), but HDL cholesterol and LDL cholesterol showed downward trend (p<0.0001). Odds ratio (OR) of likelihood of risk individuals regarding non-HDL cholesterol compared to LDL cholesterol were 0.50 (p<0.001), 1.32 (p>0.05), 2.96 (p<0.001), 6.49 (p<0.001) and 9.37 (p<0.001) for TG concentrations of up to 150 mg/dL, 151-200 mg/dL, 201-250 mg/dL, 251-300 mg/dL and 301-400 mg/dL respectively with relative risk of 0.60, 1.24, 2.43, 4.83, 5.10.

Conclusion: LDL cholesterol is a better tool for the detection of high-risk individuals than non-HDL cholesterol at TG concentration up to 150 mg/dL, whereas non-HDL cholesterol is better than LDL cholesterol at TG concentration above 200 mg/dL as a CVD risk factor.

DOI: http://dx.doi.org/10.3329/jbcps.v31i4.21004

J Bangladesh Coll Phys Surg 2013; 31: 199-203

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Published

2014-11-29

How to Cite

Saiedullah, M., Begum, S., Hayat, S., Kamahuddin, S., Rahman, M., & Khan, M. (2014). Non-HDL Cholesterol Versus LDL Cholesterol as a CVD Risk Factor in Diabetic Subjects. Journal of Bangladesh College of Physicians and Surgeons, 31(4), 199–203. https://doi.org/10.3329/jbcps.v31i4.21004

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Original Articles