Validation of the Modified Friedewald’s Formula to Calculate Low-density Lipoprotein Cholesterol in Bangladeshi Population

Authors

  • Mimi Parvin Department of Biochemistry, CMH Ghatail Cantt., Tangail
  • Muhammad Saiedullah Senior Scientific Officer & Lecturer, Department of Biochemistry & Cell Biology, Bangladesh Institute of Health Sciences (BIHS), Dhaka
  • Aminul Haque Khan Associate Professor, Department of Biochemistry, Enam Medical College, Dhaka
  • Muhammad Rezwanur Rahman Associate Professor, Dept. of Biochemistry, Delta Medical College, Dhaka
  • Md Saiful Islam Commandant, Armed Forces Institute of Pathology (AFIP), Dhaka

DOI:

https://doi.org/10.3329/jbcps.v30i3.12463

Keywords:

Friedewald’s formula, LDL cholesterol, Calculated LDL cholesterol

Abstract

Objective: A modification of Friedewalds formula was proposed to calculate LDL cholesterol in Bangladeshi population up to serum triglyceride concentration of 1000 mg/dL. The aim of this study was to validate the modification of Friedewalds formula in Bangladeshi population.

Methods: Serum total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol concentrations were measured in specimens obtained form 314 adult Bangladeshi subjects selected conveniently. LDL cholesterol concentrations were also calculated by modified Friedewalds formula and original Friedewalds formula. Results were expressed as mean ± SD and calculated LDL cholesterol was compared with measured LDL cholesterol by two-tailed paired t test and Pearsons correlation coefficient (r).

Results: The mean ± SD of measured LDL cholesterol was 138.3 ± 54.58 mg/dL. LDL cholesterol calculated by modified Friedewalds formula and original Friedewalds formula were 135.9 ± 59.26 mg/dL (P>0.05) and 123.5 ± 65.75 mg/dL (P<0.001) respectively. Compared to measured LDL cholesterol, calculated LDL cholesterol were 2.47 mg/ dL and 17.20 mg/dL lower for modified formula and original formula respectively. The correlation coefficient (r) with measured LDL cholesterol was 0.8601 (P<0.0001) for LDL cholesterol calculated by the modified Friedewalds formula and 0.8565 (P<0.0001) for the LDL cholesterol calculated by the original Friedewalds formula.

Conclusion: The study validates the modified Friedewalds formula to calculate LDL cholesterol in Bangladeshi    population.

DOI: http://dx.doi.org/10.3329/jbcps.v30i3.12463

J Bangladesh Coll Phys Surg 2012; 30: 141-144

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Published

2012-11-03

How to Cite

Parvin, M., Saiedullah, M., Khan, A. H., Rahman, M. R., & Islam, M. S. (2012). Validation of the Modified Friedewald’s Formula to Calculate Low-density Lipoprotein Cholesterol in Bangladeshi Population. Journal of Bangladesh College of Physicians and Surgeons, 30(3), 141–144. https://doi.org/10.3329/jbcps.v30i3.12463

Issue

Vol. 30 No. 3 (2012)

Section

Original Articles

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