Role of Hydroxyurea in Psoriasis - A Review

Authors

  • L Khondker FCPS Specialist in Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • AM Choudhury Professor and Chairman, Dept of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka.
  • MOR Shah Classified Specialist in Dermatology and Venereology, Combined Military Hospital (CMH), Dhaka Cantt, Dhaka
  • M Shahidullah Professor and Head, Dept of Dermatology and Venereology, Shaheed Monsur Ali Medical College Hospital, Dhaka
  • MS Islam Specialist in Dennatology and Venereology, Combined Military Hospital (CMH), Dhaka Cantt, Dhaka.
  • ARS Ahmed Consultant in Dermatology and Venereology Directorate General of Health, Mohakhali, Dhaka

DOI:

https://doi.org/10.3329/jbcps.v29i4.11330

Keywords:

Hydroxyurea, psoriasis, efficacy of hydroxyurea

Abstract

Most of the patients of psoriasis have a chronic course withthe need for continuous control of disease activity. Patientswith moderate-to-severe disease generally requirephototherapy, photo-chamotherapy or systemic agents (e.g.cyclosporine, methotrexate, oral retinoids, fumaric acidesters) to control their disease adequately. In general thesetherapeutic modalities have proven to be highly effective inthe treatment of psoriasis. However, potentially serious toxicitycan limit their long term use. In this respect, hydroxyureacompares favourably with methotrexate which has a potentialfor producing irreversible hepatic damage and cyclosporineA with its potential for dose-related nephrotoxicity.Hydroxyurea, a hydroxylated molecule of urea is commonlyused to treat chronic myelogeneous leukemia andpolycythemia vera. Recent studies suggest it as an alternativeto methotrexate in moderate-to-severe psoriasis.

 

DOI: http://dx.doi.org/10.3329/jbcps.v29i4.11330

 

J Bangladesh Coll Phys Surg 2011; 29: 219-226

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Published

2012-07-21

How to Cite

Khondker, L., Choudhury, A., Shah, M., Shahidullah, M., Islam, M., & Ahmed, A. (2012). Role of Hydroxyurea in Psoriasis - A Review. Journal of Bangladesh College of Physicians and Surgeons, 29(4), 219–226. https://doi.org/10.3329/jbcps.v29i4.11330

Issue

Section

Review Articles