Effect of antidepressant drug Flupentixol-Melitracen on locomotory behaviors of Drosophila

Authors

  • Azizul Islam Barkat Genetics and Molecular Biology branch, Department of Zoology, University of Dhaka, Dhaka, Bangladesh https://orcid.org/0000-0002-0338-4199
  • Rabeya Bosri Mehe Jabin Genetics and Molecular Biology branch, Department of Zoology, University of Dhaka, Dhaka, Bangladesh
  • Farhin Momtaz Riana Genetics and Molecular Biology branch, Department of Zoology, University of Dhaka, Dhaka, Bangladesh
  • Sumaiya Akter Genetics and Molecular Biology branch, Department of Zoology, University of Dhaka, Dhaka, Bangladesh
  • Md Shamsudduha Genetics and Molecular Biology branch, Department of Zoology, University of Dhaka, Dhaka, Bangladesh
  • Mohammad Shamimul Alam Genetics and Molecular Biology branch, Department of Zoology, University of Dhaka, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jbas.v49i2.75551

Keywords:

Depression, Fruit fly, Larval Crawling, Negative geotaxis, qPCR

Abstract

Antidepressant drugs are frequently used in the treatment of depression. Their effects on locomotory behavior have been poorly studied in human and Drosophila models. In this study, the effects of an antidepressant drug on larval crawling, negative geotaxis, and TOR gene expression were investigated in a Drosophila model. Drug-treated flies showed significantly higher activity in the negative geotaxis assay. However, no statistically significant differences were observed in the other behavioral assays or in TOR gene expression.

J. Bangladesh Acad. Sci. 49(2); 295-298: December 2025

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Published

2025-12-30

How to Cite

Barkat, A. I., Jabin, R. B. M., Riana, F. M., Akter, S., Shamsudduha, M., & Alam, M. S. (2025). Effect of antidepressant drug Flupentixol-Melitracen on locomotory behaviors of Drosophila. Journal of Bangladesh Academy of Sciences, 49(2), 295–298. https://doi.org/10.3329/jbas.v49i2.75551

Issue

Vol. 49 No. 2 (2025)

Section

Short Communication

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Copyright (c) 2025 Journal of Bangladesh Academy of Sciences

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