Immunoproliferative small intestinal disease (IPSID): An overview
Immunoproliferative small intestinal disease (IPSID) is a poorly recognized cause of malabsorption syndrome. IPSID shares clinical, morphologic, and molecular features with mucosa-associated lymphoid tissue (MALT) lymphoma, lymphoplasmacyticlymphoma, and plasma cell neoplasms, which involves mainly the proximal small intestine. It is mostly found in young adults of low socioeconomic class and poor sanitation in developing countries. Early-stage IPSID responds to antibiotics. Most untreated IPSID patients progress to lymphoplasmacytic and immunoblastic lymphoma invading the intestinal wall and mesenteric lymph nodes, and may metastasizeto a distant organ. It may be a major public health issue in developing countries.
International Journal of Hepatology Vol.1(3) 2010 pp.31-35