Synthesis and Biological Evaluation of Sugar Induced Thiazole Derivatives

Authors

  • Md Mosharef Hossain Bhuiyan Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
  • Mohammed M Matin Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
  • AFM Hafizur Rahman Department of Analytical Chemistry & Environmental Science, Training Institute for Chemical Industries (TICI), Polash, Norsingdi-1611, Bangladesh
  • Md Rabiul Alam Department of Chemistry, Comilla University, Kotbari, Cumilla, Bangladesh

DOI:

https://doi.org/10.3329/cujs.v41i1.51915

Keywords:

Aminothiazole, sugar, N-Glycoside, antimicrobial activity

Abstract

The starting materials, 2-amino-4-phenylthiazole and 2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole, were prepared by reacting thiourea with acetophenone and cyclohexanone in the presence of iodine under heating on a water bath with occasional stirring, respectively. Reaction of 2-amino-4-phenylthiazole and 2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole with various sugars afforded  corresponding N-glycoside derivatives in good yields. The structures of the synthesized N-glycosides derivatives have been established on the basis of their IR and NMR spectral data. The obtained compounds were screened for their antimicrobial activity.  Some of them were found to possess significant activities, when compared to standard drugs.

The Chittagong Univ. J. Sci. 40(1) : 68-84, 2019

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Published

2021-02-08

How to Cite

Bhuiyan, M. M. H., Matin, M. M., Rahman, A. H., & Alam, M. R. (2021). Synthesis and Biological Evaluation of Sugar Induced Thiazole Derivatives. The Chittagong University Journal of Science, 41(1), 68–84. https://doi.org/10.3329/cujs.v41i1.51915

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