Effectiveness of lateral femoral cutaneous and femoral nerve block in
managing postoperative pain for hemiarthroplasty patients
Authors
- Kazi Mahzabin Arin
Department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh https://orcid.org/0009-0004-0064-3847 - Shofina Sultana
Department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh https://orcid.org/0000-0001-8704-1785 - Ayesha Sultana
Department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
https://orcid.org/0009-0004-9107-6138 - Mohammad Abdul Hannan
Department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
https://orcid.org/0009-0006-1949-2756 - Chandra Shekhar Karmakar
Department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh https://orcid.org/0009-0009-9497-9099 - AKM Akhtaruzzaman
Department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladeshhttps://orcid.org/0000-0002-2427-1863
DOI:
https://doi.org/10.3329/bsmmuj.v18i1.76604Keywords
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Published by Bangabandhu Sheikh
Mujib Medical University
Methods: Sixty patients were randomly assigned to either the fascia iliaca compartment (FIC) block group or the lateral femoral cutaneous nerve and femoral nerve (LFCN plus FN) block group. All patients received a subarachnoid block for surgery. Pain was assessed using a visual analogue scale (VAS) in the recovery room. When patients reported VAS score 3 or 4, the FIC and LFCN plus FN blocks were performed according to group allocation. VAS scores were reassessed 20 minutes after the blocks and recorded. Subsequently, the pain was assessed using VAS at two-hour intervals until the patients required rescue analgesia.
Results: The VAS scores differed significantly between the two groups. In the LFCN plus FN block group, 13.3% reported VAS 0, 30% reported VAS 1, and the rest reported VAS 2. In the FIC block group, 53.3% reported VAS 2, and 46.7% reported VAS 3. None reported VAS 0 in the FIC group. The average time to demand rescue analgesia was 4.9 (0.8) hours in the FIC group and 9.4 (1.5) hours in the LFCN plus FN group. Adjusted time based on age, sex, body mass index, and American Society of Anesthesiologists class for the FIC block group was 6.8 (0.9) hours, while the LFCN plus FN block group recorded 7.5 (0.8) hours (P=0.003).
Conclusion: Administering the LFCN and FN block separately but simultaneously provides better postoperative analgesia than the conventional FIC block following hemiarthroplasty.
Hip fracture is a condition that predominantly affects older adults. Managing pain in these patients presents significant challenges due to the high prevalence of polypharmacy and consequential drug interactions within this population [2]. In addition, insufficient pain control can exacerbate comorbidities such as airway disease and cognitive impairment [3]. Hemiarthroplasty is performed under spinal anaesthesia. Surgical approaches may be anterior, lateral, or posterior. Most surgeons prefer the lateral approach due to its convenience and fewer complications. Following hemiarthroplasty, it is common practice to manage postoperative pain using opioid analgesics and adjuvants. However, it is essential to note that opioids have a range of adverse effects. These include nausea, vomiting, constipation, sedation, dizziness, life-threatening respiratory depression, withdrawal symptoms, hypotension, an increased risk of seizures, sweating, dysphoria, and euphoric mood. Additionally, opioids may lead to cardiovascular events, such as tachycardia, bradycardia, and palpitations. Cutaneous reactions may manifest as pruritus, urticaria, and rash [4]. Opioids also affect long-term outcomes and influence the entire lives of patients, like potentially developing opioid dependence or opioid-induced hyperalgesia [5]. For these reasons, the use of opioids is reduced by peripheral nerve blocks, and opioids are reserved for rescue analgesia. Fascia iliaca compartment (FIC) block or femoral nerve block is commonly performed for postoperative pain management in hemiarthroplasty patients. However, the study shows that none of these can adequately manage postoperative pain after hemiarthroplasty.
As the name suggests, the FIC block is a fascial plane block. Following local anaesthetic administration, drugs must diffuse to reach the femoral nerve (FN) and lateral femoral cutaneous nerve (LFCN). These two nerves run behind the fascia iliaca and are located together in the fascia iliacus space [6]. FIC block often results in inadequate blockade of the LFCN [7]. Dolan J et al. showed the success rate of ultrasound-guided FIC block is 87% [8]. For lateral approach hemiarthroplasty, a surgical incision is made in the lateral thigh. The LFCN of the thigh supplies this area. So, a significant amount of postoperative pain originates from this site. There is a substantial variation in sensory coverage among individuals because of the highly variable course of the LFCN and branches [9]. That’s why the FIC block couldn’t consistently block the LFCN of the thigh. Blocking the LFCN and FN separately with real-time ultrasound guidance may offer better pain management after hemiarthroplasty. So, this randomised control trial was designed to compare the efficacy and time to demand rescue analgesia between FIC block versus individual femoral cutaneous nerve block and FN block following hemiarthroplasty surgery.
Variables | Study group (n=30) | Control group (n=30) | P |
Age years, mean (SDa) | 64.3 (11.4) | 65.6 (16.4) | 0.13 |
< 60 | 7 (23.3) | 9 (30.0) | 0.56 |
≥ 60 | 23 (76.7) | 21 (70.0) |
|
Sex | |||
Male | 11(37.0) | 8 (27.0) | 0.21 |
Female | 19 (63.0) | 22 (77.0) |
|
Body mass index, mean (SDa) | 25.1(3.6) | 26.1(2.5) | 0.24 |
ASA class | |||
ASA class 1 | 21 (70.0) | 12 (40.0) | 0.02 |
ASA class 2 | 9 (30.0) | 18 (60.0) |
|
aSD indicates standard deviation; Values are number (%) unless indicated otherwise |
Variables | Study group (n=30) | Control group (n=30) | P |
Age years, mean (SDa) | 64.3 (11.4) | 65.6 (16.4) | 0.13 |
< 60 | 7 (23.3) | 9 (30) | 0.56 |
≥ 60 | 23 (76.7) | 21 (70) |
|
Sex | |||
Male | 11(37) | 8 (27) | 0.21 |
Female | 19 (63) | 22 (77) |
|
Body mass index, mean (SDa) | 25.1(3.6) | 26.1(2.5) | 0.24 |
ASA class | |||
ASA class 1 | 21 (70) | 12 (40) | 0.02 |
ASA class 2 | 9 (30) | 18 (60) |
|
aSD indicates standard deviation; Values are number (%) unless indicated otherwise |
After the block was given in the recovery room, 13.3% of patients in the LFCN plus FN block group reported a VAS score of 0, 30% reported a VAS score of 1, and the rest reported a VAS score of 2. On the other hand, in the FIC block group, 53.3% reported a VAS score of 2, and 46.7% of patients reported a VAS score of 3. The P for these comparisons was 0.001, indicating a significant difference in VAS scores between the two groups following blocks . The average time to demand rescue analgesia in the FIC block group was 4.9 (0.8) hours, and in the LFCN plus FN block group was 9.4 (1.5) hours (P=0.001) (Table 2). The adjusted time to demand rescue analgesia for the FIC block group was 6.8 (0.9)hours, and in the LFCN plus FN block group was 7.5 (0.8) hours (P=0.003). There was no motor weakness after the block in any group. The adjusted time to demand rescue analgesia for the FIC block group was 6.8 (0.9)hours, and in the LFCN plus FN block group was 7.5 (0.8) hours (P=0.003). There was no motor weakness after the block in any group.
Variables | Study group (n=30) | Control group (n=30) | P |
VAS, number (%) | |||
0 | 4 (13.3) | 0 (-) | 0.001 |
1 | 9 (30.0) | 0 (-) |
|
2 | 17 (56.7) | 16 (53.3) |
|
3 | 0 (-) | 14 (46.7) |
|
Time to rescue analgesia | |||
Crude mean (SD)a | 9.4 (1.5) | 4.9 (0.8) | 0.001 |
Adjustedb mean (SD)a | 7.5 (0.8) | 6.8 (0.9) | 0.003 |
aSD indicates standard deviation; bTime to rescue analgesia was adjusted according to age, sex, body mass index, and American Society of Anesthesis class |
| Study group (n=30) | Control group (n=30) | P |
VAS, number (%) | |||
0 | 4 (13.3) | 0 (-) | 0.001 |
1 | 9 (30.0) | 0 (-) |
|
2 | 17 (56.7) | 16 (53.3) |
|
3 | 0 (-) | 14 (46.7) |
|
Time to rescue analgesia | |||
Crude mean (SD)a | 9.4 (1.5) | 4.9 (0.8) | 0.001 |
Adjustedb mean (SD)a | 7.5 (0.8) | 6.8 (0.9) | 0.003 |
aSD indicates standard deviation; bTime to rescue analgesia was adjusted according to age, sex, BMI, and ASA class |
| Study group (n=30) | Control group (n=30) | P |
VAS, number (%) | |||
0 | 4 (13.3) | 0 | 0.001 |
1 | 9 (30.0) | 0 |
|
2 | 17 (56.7) | 16 (53.3) |
|
3 | 0 | 14 (46.7) |
|
Time to rescue analgesia | |||
Crude mean (SD)a | 9.4 (1.5) | 4.9 (0.8) | 0.001 |
Adjustedb mean (SD)a | 7.5 (0.8) | 6.8 (0.9) | 0.003 |
aSD indicates standard deviation; bTime to rescue analgesia was adjusted according to age, sex, BMI, and ASA class |
Categories | Number (%) |
Sex |
|
Male | 36 (60.0) |
Female | 24 (40.0) |
Age in yearsa | 8.8 (4.2) |
Education |
|
Pre-school | 20 (33.3) |
Elementary school | 24 (40.0) |
Junior high school | 16 (26.7) |
Cancer diagnoses |
|
Acute lymphoblastic leukemia | 33 (55) |
Retinoblastoma | 5 (8.3) |
Acute myeloid leukemia | 4 (6.7) |
Non-Hodgkins lymphoma | 4 (6.7) |
Osteosarcoma | 3 (5) |
Hepatoblastoma | 2 (3.3) |
Lymphoma | 2 (3.3) |
Neuroblastoma | 2 (3.3) |
Medulloblastoma | 1 (1.7) |
Neurofibroma | 1 (1.7) |
Ovarian tumour | 1 (1.7) |
Pancreatic cancer | 1 (1.7) |
Rhabdomyosarcoma | 1 (1.7) |
aMean (standard deviation) |
Due to anatomical variations of the LFCN, the FIC block often remains inadequate for postoperative analgesia. A study done by Shariat et al. reported no significant difference in postoperative pain score and 24-hour opioid consumption between FICB versus placebo in total hip arthroplasty [13]. In their study, only two patients out of sixteen had successful blocks for both femoral and lateral femoral cutaneous nerve following FIC, and the overall success rates of femoral nerve and LFCN block were 38% and 31%, respectively.
Helayel PE et al. reported that the adequate volumes of local anaesthetics in the FIC block capable of producing a block in 99% of cases were 37.3 mL [14]. A human cadaver pilot study done by Vermeylen K et al. in 2018 suggests that the volume of 40 mL is the effective volume to reach the femoral and lateral femoral cutaneous nerve [15]. Using 40 ml of local anaesthetic Bang S. et al. showed with and showed a significant opioid-sparing effect in the first 24 hours of hemiarthroplasty [16]. Though their study didn’t report any case of local anaesthetic systemic toxicity (LAST), this large volume may cause systemic toxicity. LAST is a rare but life-threatening complication of fascia iliaca compartment blocks. Most instances of toxicity are related to inadvertent intravascular administration of local anaesthetics. Following systemic absorption, bupivacaine binds avidly to voltage-gated sodium channels of cardiac muscle, leading to conduction abnormalities, contractile dysfunction, and ventricular arrhythmias [17]. Therefore, by increasing the volume of local anaesthetics, adequate analgesia can be ensured at the risk of local anaesthetic systemic toxicity.
On the contrary, we showed that only 20 ml volume is sufficient for applying separate LFCN and FN blocks with the benefit of prolonged analgesia following hemiarthroplasty.
Most of the patients who came for hemiarthroplasty were elderly people. These groups of patients remain at risk for postoperative cognitive dysfunction [18]. Opioids are associated with increased cognitive dysfunction. As the FIC block group demanded rescue analgesia early in comparison to the study group, they may require more opioids for subsequent pain control in comparison to our study group.
Our study had some limitations. We could not show the actual number of patients screened for eligibility criteria. Another limitation is resource constraints, and we could not use a continuous catheter technique for FN and LFCN blocks. However, we believe that implementing the continuous catheter technique could potentially result in opioid sparing for postoperative pain management, leading to early recovery, decreased hospital stays, and overall cost following hemiarthroplasty.