Distribution of Type Specific Human Papilloma Virus DNA Among Women of Cervical Cancer in a Tertiary Level Hospital
Human papilloma virus DNA in cervical cancer
DOI:
https://doi.org/10.3329/bmrcb.v48i1.60660Keywords:
Cervical cancer, Human papilloma virus, HPV DNA, Nanovalent vaccineAbstract
Background: Infection with high-risk human papilloma virus (HPV) has been recognised as a causal factor for development of cervical pre-cancerous and cancerous lesions. So far more than 150 types of HPV are identified. Their distribution varies from country to country, also from region to region. Background knowledge about the distribution of HPV genotypes in invasive cervical cancer is crucial to guide the introduction of prophylactic vaccines.
Objective: The study was aimed to assess the distribution of type specific human papilloma Virus DNA among cervical cancer patients.
Methods: The study was a cross sectional, observational and single centred one. It was carried out in the department of gynaecological oncology, of Bangabandhu Sheikh Mujib Medical University (BSMMU). Purposive sampling was done according to the availability of patients.
Results: HPV type 16 was detected in 35 cases (76.1%) followed by type 18 in 4 (8.7%) cases of cervical carcinoma. HPV 39, 56 and 68 were also detected, each was in 1 case (2.2 %). It was to be also found that 1 co-infection (2.2%) with HPV 33+35. HPV 16 was detected in 79.4 % of squamous cell carcinoma and in 70.0% of adenocarcinomas. HPV 18 was detected in 5.9 % of squamous cell carcinoma and 20.0% of adenocarcinomas. HPV 39 was detected in one case of small cell carcinoma (100.0%). One case of HPV 68 (2.9%) and one coinfection with HPV 33+35 (2.9 %) were found in squamous cell carcinoma. One case of HPV 56 (10.0%) was detected in adenocarcinoma of cervix. HPV DNA was not found in 3 cases of squamous cell carcinoma of cervix.
Conclusion: The distribution of HPV infection among Bangladesh women is similar to other regions of Asia. However, type specific patterns are different. The study findings will guide the formulation of HPV vaccination policies in Bangladesh, impact of vaccination programmes, to predict the efficacy of cost effective prophylactic vaccine, introduction of newer generation vaccine and finally prevention of cervical carcinoma in the country.
Bangladesh Med Res Counc Bull 2022; 48(1): 48-55
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