In vitro quality evaluation of metformin hydrochloride tablets marketed in Addis Ababa
Keywords:Metformin hydrochloride; Physicochemical bioequivalence; Drug release; Drug quality
In this study, an attempt was made to assess quality as well as pharmaceutical equivalence of six brands of metformin hydrochloride tablets marketed in Addis Ababa using in vitro methods. Friability, disintegration, dissolution and assay for the content of active ingredients were evaluated using the methods described in the United States pharmacopeia (2007). All the brands of metformin hydrochloride tablets complied with the official specification for hardness, friability, disintegration and assay. Five brands of metformin hydrochloride complied with the USP dissolution tolerance limits but Metformin Denk failed to release the stated amount. Statistical comparison for in vitro drug release indicates that some of the products of metformin hydrochloride tablets showed significant difference (P<0.05), indicating difference in their in vitro drug release that might affect the in vivo bioavailability and the bioequivalence of the products.
Bangladesh J. Sci. Ind. Res.54(2), 169-176, 2019
How to Cite
Bangladesh Council of Scientific and Industrial Research (BCSIR) holds the copyright to all contents published in Bangladesh Journal of Scientific and Industrial Research (BJSIR). A copyright transfer form should be signed by the author(s) and be returned to BJSIR.
The entire contents of the BJSIR are protected under Bangladesh Council of Scientific and Industrial Research (BCSIR) copyrights.
BJSIR is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC) Creative Commons Attribution-NonCommercial 4.0 International License which allows others remix, tweak, and build upon the articles non-commercially, and although their new works must also acknowledge and be non-commercial, they dont have to license their derivative works on the same terms.