Synthesis of potential pharmaceutically active dihydropyrimidine-2-oxo and their 2-thio analogues

Authors

  • ME Halim Department of Chemistry, University of Dhaka, Dhaka-1000
  • K Akhter Department of Chemistry, University of Dhaka, Dhaka-1000
  • M Hasan Department of Chemistry, University of Dhaka, Dhaka-1000
  • MM Rahman Department of Chemistry, Jagannath University, Dhaka-1100
  • UKR Romman Department of Chemistry, University of Dhaka, Dhaka-1000
  • MG Ahmed Department of Chemistry, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bjsir.v53i4.39198

Keywords:

Cyclocondensation, Aldehydes, β - dicarbonyl, Urea and thiourea

Abstract

The Biginelli one - pot three-component cyclocondensation was applied to prepare 3, 4 - dihydropyrimidin - 2 (1H) – ones from aldehydes, β-dicarbonyl compounds and urea (or thiourea) using ZnCl2 as a catalyst. The method offers several advantages including short reaction times and easy experimental work up procedures.

Bangladesh J. Sci. Ind. Res.53(4), 327-332, 2018

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Published

2018-12-09

How to Cite

Halim, M., Akhter, K., Hasan, M., Rahman, M., Romman, U., & Ahmed, M. (2018). Synthesis of potential pharmaceutically active dihydropyrimidine-2-oxo and their 2-thio analogues. Bangladesh Journal of Scientific and Industrial Research, 53(4), 327–332. https://doi.org/10.3329/bjsir.v53i4.39198

Issue

Section

Short Communications