Synthesis of potential pharmaceutically active dihydropyrimidine-2-oxo and their 2-thio analogues
Keywords:Cyclocondensation, Aldehydes, β - dicarbonyl, Urea and thiourea
The Biginelli one - pot three-component cyclocondensation was applied to prepare 3, 4 - dihydropyrimidin - 2 (1H) – ones from aldehydes, β-dicarbonyl compounds and urea (or thiourea) using ZnCl2 as a catalyst. The method offers several advantages including short reaction times and easy experimental work up procedures.
Bangladesh J. Sci. Ind. Res.53(4), 327-332, 2018
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