Antioxidant properties of Ageratum conyzoides L. Asteraceae leaves

Authors

  • FO Adetuyi Biochemistry unit, Chemical Sciences, Ondo State University of Science and Technology, PMB 353, Okitipupa, Ondo State
  • KO Karigidi Biochemistry unit, Chemical Sciences, Ondo State University of Science and Technology, PMB 353, Okitipupa, Ondo State
  • ES Akintimehin Biochemistry unit, Chemical Sciences, Ondo State University of Science and Technology, PMB 353, Okitipupa, Ondo State
  • ON Adeyemo Biochemistry unit, Chemical Sciences, Ondo State University of Science and Technology, PMB 353, Okitipupa, Ondo State

DOI:

https://doi.org/10.3329/bjsir.v53i4.39190

Keywords:

A. conyzoides, Antioxidants, Aqueous, Methanol, Total phenol and Fe2 induced lipid peroxidation

Abstract

In vitro antioxidative and anti-lipid peroxidative properties of aqueous and methanol extracts of Ageratum conyzoides leaves were studied in controlling erectile dysfunction caused by oxidative stress. Methanol extract gave a significantly (P ˂ 0.05) higher content of total phenolic (61.4 mgGAE/g), total flavonoid (42.2 mgQE/g), ascorbic (10.1 mgAAE/100g) and phosphomolybdate (45.8 mgAAE/g) than the aqueous extract. The result showed that the extracts have high antioxidant activities. However, the methanol extract showed a higher DPPH and hydrogen peroxide scavenging activities over aqueous extract but the aqueous extract had a higher reducing power. The methanol extract exhibited a greater inhibition against lipid peroxidation induced by Fe2+ in rat pancreas and penile tissue homogenate exemplified by their least IC50 (94.21 μg/ml in pancreas) and (75.95 μg/mL in penile tissue) while in rat brain homogenate the aqueous extract exhibited a greater inhibition against lipid peroxidation induced by Fe2+ with least IC50 of 91.74 μg/mL. Hence, these extracts can be used as a potent natural antioxidant against free radicals and as a natural source of combating erectile dysfunction caused by oxidative stress. The extracts of Ageratum conyzoides leaves could be useful therapeutically as erectogenic agent.

Bangladesh J. Sci. Ind. Res.53(4), 265-276, 2018

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Published

2018-12-09

How to Cite

Adetuyi, F., Karigidi, K., Akintimehin, E., & Adeyemo, O. (2018). Antioxidant properties of Ageratum conyzoides L. Asteraceae leaves. Bangladesh Journal of Scientific and Industrial Research, 53(4), 265–276. https://doi.org/10.3329/bjsir.v53i4.39190

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Articles