A Study on the Synthesis of 5, 7-Diaryl-1,2,3,4-tetrahydro-2, 4-dioxo-5H-pyrano [2,3-d]pyrimidines

Authors

  • MG Ahmed Department of Chemistry, University of Dhaka, Dhaka-1000
  • UKR Romman Department of Chemistry, University of Dhaka, Dhaka-1000
  • SM Ahmed bFaculty of Science, American International University-Bangladesh (AIUB), Banani, Dhaka-1213, Bangladesh
  • Khondaker Akhter Department of Chemistry, University of Dhaka, Dhaka-1000
  • ME Halim Department of Chemistry, University of Dhaka, Dhaka-1000
  • M Salauddin Department of Chemistry, University of Dhaka, Dhaka-1000

Keywords:

pyrimidines

Abstract

5,7-Diphenyl-1,2,3,4-tetrahydro-2,4-dioxo-5H-pyrano[2,3-d]pyrimidine (4a) has been synthesized in single-step by the condensation of barbituric acid (1) with benzylideneacetophenone (2a) in glacial acetic acid in the presence of phosphorous pentoxide. Reaction of barbituric acid (1) with arylideneacetophenones (2b-d) which gave the corresponding adducts of 5-(1,3-diaryl-1-oxopropyl) pyrimidine (1H, 3H, 5H)-2,4,6-triones (3a-c) previously in 50 % aqueous ethanol which on further reflux in gl. acetic acid in the presence of phosphorous pentoxide also gave the corresponding pyranopyrimidines 5,7-diaryl-1,2,3,4-tetrahydro-2,4-dioxo-5H-pyrano [2,3- d]pyrimidines (4b-d). The structures of the compounds 4a-d were characterized by their UV, IR, 1H NMR and 13C NMR spectral data. Bangladesh J. Sci. Ind. Res. 41(3-4), 119-128, 2006
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How to Cite

A Study on the Synthesis of 5, 7-Diaryl-1,2,3,4-tetrahydro-2, 4-dioxo-5H-pyrano [2,3-d]pyrimidines. (2007). Bangladesh Journal of Scientific and Industrial Research, 41(3), 119-128. https://doi.org/10.3329/bjsir.v41i3.281

Issue

Vol. 41 No. 3 (2006)

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Articles

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How to Cite

A Study on the Synthesis of 5, 7-Diaryl-1,2,3,4-tetrahydro-2, 4-dioxo-5H-pyrano [2,3-d]pyrimidines. (2007). Bangladesh Journal of Scientific and Industrial Research, 41(3), 119-128. https://doi.org/10.3329/bjsir.v41i3.281