Bilateral Periventricular Nodular Heterotopia due to Disruption of MAP1B and MYH2 Genes: A Rare Case Report

Authors

  • Afroza Parvin Department of Radiology and Imaging, Popular Medical College Hospital, Dhanmondi, Dhaka
  • Shaoli Sarker Department of Radiology and Department of Radiology and Imaging, Popular Medical College Hospital, Dhanmondi, DhakaImaging, Bangladesh Shishu Hospital and Institute, Dhaka
  • Hosneara Akter Department of Radiology and Imaging, Bangladesh Shishu Hospital and Institute, Dhaka
  • Mohammed Uddin Centre for Applied and Translational Genomics, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, UAE

Keywords:

Epilepsy, PVNH, Congenital anomaly, genes

Abstract

We report a rare case of bilateral periventricular nodular heterotopia (PVNH), a congenital brain abnormality resulting from failed neural cell migration associated with disruption of MAP1B and MYH2 genes which are involved in microtubule assembly in neurogenesis. A 1.2 years old girl presented with symptoms of focal seizure since 9 months of age. The patient’s clinical evaluation, in conjunction with CT, MRI brain without contrast and genetic testing, led to the final diagnosis

Abstract
5
PDF
0

Downloads

Published

2026-06-10

How to Cite

Bilateral Periventricular Nodular Heterotopia due to Disruption of MAP1B and MYH2 Genes: A Rare Case Report. (2026). Bangladesh Journal of Radiology and Imaging, 33(1), 50-53. https://doi.org/10.3329/bjri.v33i1.90682

Issue

Vol. 33 No. 1 (2025)

Section

Case Reports

License

Copyright (c) 2026 Afroza Parvin, Shaoli Sarker, Hosneara Akter, Mohammed Uddin

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Bilateral Periventricular Nodular Heterotopia due to Disruption of MAP1B and MYH2 Genes: A Rare Case Report. (2026). Bangladesh Journal of Radiology and Imaging, 33(1), 50-53. https://doi.org/10.3329/bjri.v33i1.90682