Antidiarrheal and antispasmodic activities of Salvia officinalis are mediated through activation of K+ channels


  • Aslam Khan Natural Products Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800
  • Najeeb-ur- Rehman Natural Products Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800
  • Khalid M. AlKharfy Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh
  • Anwarul-Hassan Gilani Natural Products Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800



Antidiarrheal, Antispasmodic, Potassium channel, Salvia officinalis, Sage


This study was conducted to provide pharmacological basis for the medicinal use of Salvia officinalis in diarrhea. The crude extract of S. officinalis was studied using the in vivo and in vitro assays.  The crude extract inhibited castor oil-induced diarrhea in mice at the dose of 100 and 300 mg/kg. In isolated rabbit jejunum, it caused a dose-dependent (0.1-3 mg/mL) relaxation of spontaneous as well as low K+ (25 mM) and high K+ (80 mM)-induced contractions, being distinctly more potent on low K+. Pretreatment of tissue with 4-aminopyridine (1 mM) almost completely blocked the inhibitory effect of crude extract on low K+.  These results indicate that the crude extract of S. officinalis possesses antidiarrheal and antispasmodic activities mediated possibly through the dominant activation of voltage-dependent K+ channels and this study provides sound pharmacological basis for its medicinal use in diarrhea and gut spasm.


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How to Cite

Khan, A., N.- ur-. Rehman, K. M. AlKharfy, and A.-H. Gilani. “Antidiarrheal and Antispasmodic Activities of Salvia Officinalis Are Mediated through Activation of K+ Channels”. Bangladesh Journal of Pharmacology, vol. 6, no. 2, Oct. 2011, pp. 111-6, doi:10.3329/bjp.v6i2.9156.



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