In vitro free radical scavenging activity of Ixora coccinea L

  • Moni Rani Saha Phytochemistry and Pharmacology Laboratory, Department of Pharmacy, Stamford University Bangladesh, Dhaka 1217
  • Md. Ashraful Alam Phytochemistry and Pharmacology Laboratory, Department of Pharmacy, Stamford University Bangladesh, Dhaka 1217
  • Raushanara Akter Phytochemistry and Pharmacology Laboratory, Department of Pharmacy, Stamford University Bangladesh, Dhaka 1217
  • Rumana Jahangir Phytochemistry and Pharmacology Laboratory, Department of Pharmacy, Stamford University Bangladesh, Dhaka 1217
Keywords: Antioxidant, Free radical, Ixora coccinea

Abstract

Antioxidant activity of the methanol extract of Ixora coccinea L. was determined by DPPH free radical scavenging assay, reducing power and total antioxidant capacity using phosphomolybdenum method. Preliminary phytochemical screening revealed that the extract of the flowerof I. coccinea possesses flavonoids, steroids and tannin materials. The extract showed significant activities in all antioxidant assays compared to the standard antioxidant in a dose dependent manner and remarkable activities to scavenge reactive oxygen species (ROS) may be attributed to the high amount of hydrophilic phenolics. In DPPH radical scavenging assay the IC50 value of the extract was found to be 100.53 μg/mL while ascorbic acid had the IC50value 58.92 μg/mL. Moreover, I. coccinea extract showed strong reducing power and total antioxidant capacity.

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Published
2008-07-15
How to Cite
Saha, M., M. Alam, R. Akter, and R. Jahangir. “In Vitro Free Radical Scavenging Activity of Ixora Coccinea L”. Bangladesh Journal of Pharmacology, Vol. 3, no. 2, July 2008, pp. 90-96, doi:10.3329/bjp.v3i2.838.
Section
Research Articles