A comparative study of the anti-inflammatory effect of aqueous extract of neem leaf and dexamethasone
The anti-inflammatory effect of aqueous extract of neem leaf (400 mg/kg body weight) was compared with that of dexamethasone (0.75 mg, intraperitoneally) by administering one hour before the formalin injection and once daily for 7 days in rats. The percentage of inhibition of paw edema in case of neem after 3 hours, 6 hours, on day 3, on day 7 after formalin injection were 28%, 40%, 45%, 58% respectively and that in case of dexamethasone after 3 hours, 6 hours, on day 3, on day 7 after formalin injection were 43%, 58%, 61%, 65% respectively. The reduction was statistically significant in each case (p<0.001). The present study suggests that anti-inflammatory effect of neem extract is less than that produced by dexamethasone.
Biswas K, Chattopathyay I, Banerjee RK, Bandyopathyay U. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci. 2002; 82: 1336-45.
Chatterjee A, Pakrashi S. (ed). The treatise on Indian medical plants. 3rd ed. 1994, p 76.
Chattopadhyay RR. Study of Possible biochemical mode of anti-inflammatory action of Azadirachta indica in rats. Indian J Exper Biol. 1998; 36: 418-20.
Chattopadhyay RR, Chattopadhyay RN, Maitra SK. Study of possible mechanism of anti-inflammatory activity of Azadirachta indica leaf extract. Indian J Pharmacol. 1993; 25: 99-100.
Khosla P, Sangeeta B, Singh J and Srivastava RK. Study of antinociceptive activity of Azadirachta indica (neem) in rats. Indian J Pharmacol. 2000; 32: 372-74.
Damas J, Liegeosis JF. The inflammatory reaction induced by formalin in rats paw. Naunyn Schmiedebegs Arch Pharmacol. 1999; 359: 220-27.
Kumar V, Abbas AK, Fausto N. Pathologic basis of disease. 7th ed. Elsevier Saunder, 2004.
Okpanyi SN, Ezeukwu GC. Studies of anti-inflammatory and anti-pyretic activities of Azadirachta indica on inflammation in spraque Dawlea male rats. Planta Med. 1981; 41: 34-39.
Pallai NR, Shanthakumari G. Study of anti-arthritic and anti-inflammatory actions of nimbidin on inflammation in albino rats. Planta Med. 1981; 43: 59-63.
Rang HP, Dale MM, Ritter JM, Moore PK. (eds). Pharmacology. London, Churchill Livingstone, 2003, pp 244-60.
Ray A, Gupta JK, Lahiri SC. Studies on anti-inflammatory, analgesic and anti-pyretic activities of some Indian acids. Indian J Physiol Pharmacol. 1980; 24: 310-15.
Tidjani MA, Dupont C, Wepierre J. Azadirachta indica stem bark extract anti-inflammatory activity. Planta Med Phytother. 1989; 23: 25966.
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