A comparative study of the anti-inflammatory effect of aqueous extract of neem leaf and dexamethasone

  • Abu Syed Md. Mosaddek Department of Pharmacology, Rajshahi Medical College, Rajshahi
  • Md. Mamun Ur Rashid Department of Pharmacology, Rajshahi Medical College, Rajshahi
Keywords: Dexamethasone, Neem, Paw edema

Abstract

The anti-inflammatory effect of aqueous extract of neem leaf (400 mg/kg body weight) was compared with that of dexamethasone (0.75 mg, intraperitoneally) by administering one hour before the formalin injection and once daily for 7 days in rats. The percentage of inhibition of paw edema in case of neem after 3 hours, 6 hours, on day 3, on day 7 after formalin injection were 28%, 40%, 45%, 58% respectively and that in case of dexamethasone after 3 hours, 6 hours, on day 3, on day 7 after formalin injection were 43%, 58%, 61%, 65% respectively. The reduction was statistically significant in each case (p<0.001). The present study suggests that anti-inflammatory effect of neem extract is less than that produced by dexamethasone.

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How to Cite
Mosaddek, A., and M. Rashid. “A Comparative Study of the Anti-Inflammatory Effect of Aqueous Extract of Neem Leaf and Dexamethasone”. Bangladesh Journal of Pharmacology, Vol. 3, no. 1, 1, pp. 44-47, doi:10.3329/bjp.v3i1.836.
Section
Research Articles