6-Formylindolo[3,2-b]carbazole promotes proliferation of adipose-derived mesenchymal stem cells via activation of the Ahr–IL-6 signaling axis

Authors

  • Thanh Trung Tran Institute of Biology, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
  • Thi Tien Vu Institute of Biology, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
  • Kien Trung Tran Hanoi Obstetrics and Gynecology Hospital, Hanoi, Vietnam.
  • Taisuke Nakahama Department of RNA Biology and Neuroscience, Osaka University, Suita, Osaka, Japan.
  • Nam Trung Nguyen Institute of Biology, Vietnam Academy of Science and Technology, Hanoi, Vietnam.

DOI:

https://doi.org/10.3329/bjp.v20i4.83467

Keywords:

AD-MSC expansion, aryl hydrocarbon receptor, IL-6, FICZ

Abstract

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References

Dorronsoro A, Lang V, Ferrin I, Fernandez-Rueda J, Zabaleta L, Perez-Ruiz E, Sepulveda P, Trigueros C. Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation. Sci Rep. 2020; 10: 21853.

Huang J, Wang Y, Zhou Y. Beneficial roles of the AhR ligand FICZ on the regenerative potentials of BMSCs and primed cartilage templates. RSC Adv. 2022; 12: 11505-16.

Kim D. Method for culturing adiposed derived stem cell. 2013: Patent Numbers: 10-1624514, 10-1643315, 10-1590416.

Larigot L, Juricek L, Dairou J, Coumoul X. AhR signaling pathways and regulatory functions. Biochim Open. 2018; 7: 1-9.

Nguyen NT, Hanieh H, Nakahama T, Kishimoto T. The roles of aryl hydrocarbon receptor in immune responses. Int Immunol 2013; 25: 335043.

Seo MS, Baek J, Jeon MS. Role of the aryl hydrocarbon receptor in the self-renewal, differentiation, and immuno-modulation of adult stem cells. Immune Netw. 2025; 25: e1.

Tanaka Y, Uchi H, Hashimoto-Hachiya A, Furue M. Trypto-phan photoproduct FICZ upregulates IL1A, IL1B, and IL6 expression via oxidative stress in keratinocytes. Oxid Med Cell Longev. 2018; 2018: 9298052.

Tsuji G, Takahara M, Uchi H, Matsuda T, Chiba T, Takeuchi S, Yasukawa F, Moroi Y, Furue M. Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: The basis of its anti-inflammatory effect. J Invest Dermatol. 2012; 132: 59-68.

Vrzal R, Marcalíkova A, Krasulova K, Zemánkova L, Dvorak Z. Jasmone is a ligand-selective allosteric antagonist of Aryl hydrocarbon receptor (AhR). Int J Mol Sci. 2023; 24: 15655.

Yin J, Sheng B, Qiu Y, Yang K, Xiao W, Yang H. Role of AhR in positive regulation of cell proliferation and survival. Cell Prolif. 2016; 49: 554-60.

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Published

2025-10-27

How to Cite

Tran, Thanh Trung, et al. “6-Formylindolo[3,2-b]carbazole Promotes Proliferation of Adipose-Derived Mesenchymal Stem Cells via Activation of the Ahr–IL-6 Signaling Axis”. Bangladesh Journal of Pharmacology, vol. 20, no. 4, Oct. 2025, pp. 169-72, doi:10.3329/bjp.v20i4.83467.

Issue

Vol. 20 No. 4 (2025)

Section

Letter to the Editor

License

Copyright (c) 2025 Thanh Trung Tran, Thi Tien Vu, Kien Trung Tran, Taisuke Nakahama, Nam Trung Nguyen

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