Cardioprotective activity of ethanolic extract of Callistemon lanceolatus leaves on doxorubicin-induced cardiomyopathy in rats

  • Momin Firoz Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
  • Kalai Bharatesh Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
  • Patole Nilesh Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
  • Godse Vijay Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
  • Shikalgar Tabassum Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
  • Naikwade Nilofar Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
Keywords: Antioxidant, Blood pressure, Cardiac toxicity, Doxorubicin, ECG

Abstract

The  cardioprotective  effect  of  ethanol extract of Callistemon lanceolatus  leaves (100  and  200  mg/kg) against doxorubicin-induced cardiomyopathy was studied. Rats were pretreated with the extract for 7 days and simultaneous treatment with doxorubicin along with the extracts for the next 14 days. After 24 hours of last dose of doxorubicin, ECG, invasive blood pressure, serum markers (creatine kinase-MB, lactate dehydrogenase, serum transaminases), tissue antioxidant markers (catalase, superoxide dismutase) and extent of lipid peroxidation (malondialdehyde) were studied. The elevated ST segment, decreased blood pressure, increased level of serum enzymes and decreased level of tissue antioxidant markers were observed in doxorubicin treatment (p<0.01). While 200 mg/kg extract significantly reduced the elevated levels of the serum enzymes and restores the ECG and blood pressure to normal, also significantly increased the tissue antioxidant levels, while decreased the malondialdehyde level (p<0.01) when compared with the control. The histopathological study confirmed the cardioprotection.

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Author Biographies

Momin Firoz, Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
 
Kalai Bharatesh, Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
 
Patole Nilesh, Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
 
Godse Vijay, Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli
 

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Published
2011-08-10
How to Cite
Firoz, M., K. Bharatesh, P. Nilesh, G. Vijay, S. Tabassum, and N. Nilofar. “Cardioprotective Activity of Ethanolic Extract of Callistemon Lanceolatus Leaves on Doxorubicin-Induced Cardiomyopathy in Rats”. Bangladesh Journal of Pharmacology, Vol. 6, no. 1, Aug. 2011, pp. 38-45, doi:10.3329/bjp.v6i1.8154.
Section
Research Articles