Pharmacological basis for the medicinal use of cardamom in asthma

Arif ullah Khan, Qaiser Jabeen Khan, Anwar Hassan Gilani


Cardamom (Elettaria cardamomum) is widely used in folk medicine for the treatment of asthma. This study describes its airways relaxant potential, with elucidation of possible underlying mechanism. Crude extract of cardamom which tested positive for alkaloids, flavonoids, saponins, sterols and tannins, when tested against carbachol-mediated bronchoconstriction in rats under anesthesia, it dose-dependently (10-100 mg/kg) suppressed the carbachol (1 µmol/kg)-evoked increase in the inspiratory pressure. In isolated rabbit trachea tissues, crude extract of cardamom caused relaxation of both carbachol (1 µM) and high K+ (80 mM)-induced contractions, like that caused by verapamil, suggesting its Ca++ channel blockade action. These results indicate that cardamom exhibits bronchodilatory effect, mediated through Ca++ antagonist mechanism, which provides sound mechanistic background for its medicinal use in asthma.


Cardamom; Bronchodilation; Ca++ channel blocker; Asthma

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Barnes PJ. Drugs for asthma. Br J Pharmacol. 2006; 147: S297-S303.

Duke JA. Handbook of phytochemical constituents of GRAS herbs and other economical plants. London, CRC Press, 1992, pp 239-40.

Duke JA, Bogenschutz-Godwin MJ, DuCelliar J, Duke PK. Hand book of medicinal herbs. 2nd ed. Boca Raton, CRC Press, 2002, pp 153-54.

Fleckenstein A. Specific pharmacology of Ca++ in cardiac pacemakers and vascular smooth muscle. Rev Pharmacol Toxicol. 1977; 17: 149-66.

Ghayur MN, Khan H, Gilani AH. Antispasmodic, bronchodilator and vasodilator activites of (+)-catechin, a naturally occurring flavonoid. Arch Pharm Res. 2007; 30: 970-75.

Gilani AH, Bashir S, Khan A. Pharmacological basis for the use of Borago officinalis in gastrointestinal, respiratory and cardiovascular disorders. J Ethnopharmacol. 2007; 114: 393-99.

Gilani SN, Khan A, Gilani AH. Pharmacological basis for the medicinal use of Zanthoxylum armatum in gut, airways and cardiovascular disorders. Phytother Res. 2010; 24: 553-58.

Godfraind T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev. 1986; 38: 321-416.

Gopalakrishnan M, Narayanan CS, Grenz M. Non saponifiable lipid constituents of cardamom. J Agr Food Chem. 1990; 38: 2133-36.

Kapoor LD. Handbook of Ayurvedic medicinal plants. CRC Press, Boca Raton, 1990, p 172.

Khan A, Gilani AH. Antidiarrheal, antisecretory and bronchodilatory activities of Hypericum perforatum. Pharm Biol. 2009; 47: 962-67.

Nadkarni KM. Indian materia medica. 3rd ed. Bombay, Popular Prakashan, 1976, pp 475-76.

National Research Council. Guide for the care and use of laboratory animals. Washington, National Academy Press, 1996, pp 1-7.

Twiss MA, Harman E, Chesrown S, Handeles L. Efficacy of calcium channel blockers as maintenance therapy for asthma. Br J Clin Pharmacol. 2002; 53: 243-49.


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Copyright (c) 2011 Arif ullah Khan, Qaiser Jabeen Khan, Anwar Hassan Gilani

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Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is a single-blinded peer-reviewed, video component, open access official publication of the Bangladesh Pharmacological Society (BDPS). eISSN: 1991-0088. For contact: Editor-In-Chief