Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials


  • Sougat Sourendra Sarkar Glenmark Pharmaceuticals Ltd, Glenmark House, Mumbai,



Indapamide, Meta-analysis, Perindopril, Prevention, Stroke, Vascular disease


Perindopril/indapamide combination has been shown to reduce cardiovascular risk in different groups of patients. A total of 18,529 patients (9,272 receiving perindopril/indapamide and 9,257 receiving placebo) were included in this meta-analysis involving three large randomized clinical trials-ADVANCE, PROGRESS and HYVET. A non-significant reduction in fatal and non-fatal stroke was seen (Odds ratio 0.73; 95% Confidence Interval 0.49 to 1.09; z=1.52 and p= 0.13). The combination was associated with a significantly reduction of vascular death (Odds ratio 0.79; 95% Confidence Interval 0.69 to 0.90; z=3.48 and p=0.0005) and major cardio-vascular events (Odds ratio 0.72; 95% Confidence Interval 0.53 to 0.97; z=2.15 and p= 0.03). Fixed-combination of Perindopril and indapamide substantially reduced major cardiovascular event and vascular death. However, effect on stroke needs further evaluation.


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How to Cite

Sarkar, S. S. “Combination of perindopril/Indapamide in Secondary Prevention of Stroke and Other Vascular Events: A Combined Analysis of ADVANCE, PROGRESS and HYVET Trials”. Bangladesh Journal of Pharmacology, vol. 6, no. 1, July 2011, pp. 25-33, doi:10.3329/bjp.v6i1.7920.