Synthesis of some NH-derivatives of ciprofloxacin as antibacterial and antifungal agents

  • Md. Golam Rabbani Department of Chemistry, Jahangirnagar University, Savar, Dhaka
  • Md. Rabiul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka
  • Mesbahuddin Ahmad Department of Pharmacy, Gono Bishwabidyalay, Savar, Dhaka
  • Abugafar Md. Lokman Hossion Department of Medical and Bioengineering Science, Okayama University, Okayama
Keywords: Antibacterial, Antifungal, Ciprofloxacin, Schotten-Baumann method

Abstract

Five NH-derivatives of ciprofloxacin (2-6) have been prepared by acetylation/benzoylation on ciprofloxacin (1) in order to carry out screening for antibacterial activities on some Gram-positive and Gram-negative bacteria. The antifungal activity of these compounds has also been made against Candida albicans. All of the derivatives have shown enhanced activities against Gram-negatives bacteria than parent antibiotic, ciprofloxacin among which compounds 2 and 6 are the most potent agents. Regarding the antifungal activity all of the compounds have shown highest activity than ciprofloxacin. All the compounds have been characterized with spectral analysis.

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Published
2011-06-17
How to Cite
Rabbani, M., M. Islam, M. Ahmad, and A. Hossion. “Synthesis of Some NH-Derivatives of Ciprofloxacin As Antibacterial and Antifungal Agents”. Bangladesh Journal of Pharmacology, Vol. 6, no. 1, June 2011, pp. 8-13, doi:10.3329/bjp.v6i1.7720.
Section
Research Articles