Bioactive peptides SL-13R and KS-13 enhance human adipose-derived mesenchymal stem cell proliferation in vitro




AD-MSC expansion, Bioactive peptide, KS-13, Mesenchymal stem cell, SL-13R


No abstract


Download data is not yet available.


Akbarian M, Khani A, Eghbalpour S, Uversky VN. Bioactive peptides: Synthesis, sources, applications, and proposed mechanisms of Action. Int J Mol Sci. 2022; 23: 1445.

Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010; 329: 1345-48.

Dayem AA, Lee SB, Lim KM, Kim A, Shin HJ, Vellingiri B, Kim YB, Cho SG. Bioactive peptides for boosting stem cell culture platform: Methods and applications. Biomed Pharmacother. 2023; 160: 114376.

Han H, Jayaraman A, Safe S, Chapkin RS. Targeting the aryl hydrocarbon receptor in stem cells to improve the use of food as medicine. Curr Stem Cell Rep. 2020; 6: 109-18.

Han YS, Yun SP, Ko HS, Lee SH. Therapeutic effect of genistein-stimulated human mesenchymal stem cells in myocardial infarction. J Transplant Stem Cel Biol. 2014; 1: 7.

Kim D. Method for culturing adiposed derived stem cell. 2013: Patent Numbers: 10-1624514, 10-1643315, 10-1590416.

Nguyen NT, Hanieh H, Nakahama T, Kishimoto T. The roles of aryl hydrocarbon receptor in immune responses. Int Immunol. 2013; 25: 335–43.

Nii T, Konno K, Matsumoto M, Bhukhai K, Borwornpinyo S, Sakai K, Hongeng S, Sugiyama D. The bioactive peptide SL-13R expands human umbilical cord blood hematopoietic stem and progenitor cells in vitro. Molecules 2021; 26: 1995.

Tran MD, Tran T, Nguyen N, Chu H, Nakahama T, Nguyen N. Anti-inflammatory activity of 9-hydroxycanthin-6-one extracted from hairy-root cultures of Eurycoma longifolia potentially via aryl hydrocarbon receptor induction. Bangladesh J Pharmacol. 2022; 17: 102-04.

Wang L, Wang N, Zhang W, Cheng X, Yan Z, Shao G, Wang X, Wang R, Fu C. Therapeutic peptides: current applications and future directions. Sig Transduct Target Ther. 2022; 7: 48.




How to Cite

Tran, T. T. ., K. T. . Tran, D. . Kim, and N. T. Nguyen. “Bioactive Peptides SL-13R and KS-13 Enhance Human Adipose-Derived Mesenchymal Stem Cell Proliferation in Vitro”. Bangladesh Journal of Pharmacology, vol. 19, no. 2, June 2024, pp. 69-71, doi:10.3329/bjp.v19i2.72739.



Letter to the Editor