Protective effect of dried fruits of Carica papaya on hepatotoxicity in rat


  • Md. Zafor Sadeque Department of Pharmacology and Therapeutic, Dhaka Medical College, Dhaka
  • Zinnat Ara Begum Department of Pharmacology and Therapeutic, Dhaka Medical College, Dhaka



Carica papaya, Hepatoprotective effect, Carbon tetrachloride


Aqueous and ethanol extracts of Carica papaya has been evaluated for its hepatoprotective activity in rats. The aqueous and ethanol extracts of C. papaya showed significant hepatoprotection against carbon tetrachloride induced hepatotoxicity. The protective activity was evaluated by using biochemical parameters such as serum bilirubin, serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. The histopathological changes of liver were compared with control.


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Author Biography

Zinnat Ara Begum, Department of Pharmacology and Therapeutic, Dhaka Medical College, Dhaka



Ahmed FS. Prevalence of transfusion transmitted viruses (HBV, HCV, HIV) among multitransfused thalassamic children. MD Thesis, Dhaka, BSMMU, 2005.

Al-Qarawi AA, Abdel-Rahman HA, El-Mougy SA. Hepatoprotective activity of Licorice in rat liver injury model. J Herbs Spices Med Plants. 2001; 8: 7-14.

Balamurugan G, Muthusamy P. Observation of the hepatoprotective and antioxidant activities of Trianthema decandra Linn. (Vallai sharunnai) roots on carbon tetrachloride-treated rats. Bangladesh J Pharmacol. 2008; 3: 83-89.

Eva EO. Comparative hepatoprotective effects of Andrographis paniculata and alpha-tocopherol in paracetamol-induced liver damage in rats. MPhil Thesis, Dhaka, Dhaka Medical College, 2004.

Ghani A. Medicinal plants of Bangladesh. 2nd ed. Dhaka, Asiatic Society of Bangladesh, 2003, pp 1-149.

Iqbal MJ, Dewan FZ, Chowdhury SAR, Mamun MIR, Moshiuzzaman M, Begum M. Pre-treatment by n-hexane extract of Phyllanthus niruri can alleviate paracetamol-induced damage of the rat live. Bangladesh J Pharmacol. 2007; 2: 43-48.

Jayakar B, Dube R, Rama SKV, Vimala S. Effects of caseria esculenta on paracetamol induced hepatotoxicity. Indian Drugs 1999; 36: 263-64.

Kumar V, Cotran RS, Robbins SL. Cell injury and adaptation. In: Basic pathology. Kumar V, Cotran RS, Robbins SL (eds). 5th ed. Prism Books, India, 1992, pp 1-24.

Kaplowitz N, Aw TY, Simon FR, Stolz A. Drug induced hepatotoxicity. Ann Intern Med. 1986; 104: 826-39. PMid: 3518564

Ruckmani K, Kavimani S, Anandan R, Jayakar B. Effect of Moringa oliefera Lam on paracetamol-induced hepatotoxicity. Indian J Pharm Sci. 1998; 60: 33-35.

Rajkapoor B, Jayakar B, Kavimani S, Murugesh N. Effect of dried fruits of Carica papaya Linn on hepatotoxicity. Biol Pharm Bull. 2002; 25: 1645-46.

Samson JA. Tropical fruits. 2nd ed. Longman Scientific and Technical Publication, 1986, pp 256-69.

Thakare SP, Jain HN, Patil SD, Upadhyay UM. Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats. Bangladesh J Pharmacol. 2009; 4: 126-30.

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How to Cite

Sadeque, M. Z., and Z. A. Begum. “Protective Effect of Dried Fruits of Carica Papaya on Hepatotoxicity in Rat”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, July 2010, pp. 48-50, doi:10.3329/bjp.v5i1.5305.



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